結(jié)構(gòu)基序預(yù)測(cè)蛋白質(zhì)功能(完整版)
【正文】 ome atoms of aligand within 5 A radius. 2. Similarity between binding site structures To pare binding site structures, we used the GIRAF structural search and alignment program with some modifications to enable faster database search and flexible alignments (unpublished). After allagainstall parisons of binding sites, elementary motifs were defined as pletelinkage clusters with a cutoff GIRAF score of 15. The GIRAF score is defined as The results of allagainstall parison of binding sites and classifications are made available for download at ? NA and NB分別是 A、 B原子中的結(jié)合位點(diǎn)數(shù)目。我們把這些簇看做 elementary elementary motifs 的集稱(chēng)為亞基的 posite 兩個(gè)亞基有共同的 elementary motifs 可以推斷他們有共 同的 posite motif。 To date, there have been many methods for detecting potential ligand binding sites based on structural similarity of proteins [14,16–22]. Most of these methods are targeted at predicting protein functions at the level of ligand binding and catalytic activity. There have also been many studies on proteinprotein interaction interfaces to understand biological functions of proteins in cellular contexts 。因此，我們不僅要確定個(gè) 體蛋白的相互作用，也要考慮潛在的蛋白質(zhì)相互作 用，這些相互作用或許可以充分描述蛋白質(zhì)的功 能，也能從同源蛋白中區(qū)分它們的不同功能。同樣從相似度矩陣或距離矩陣出發(fā)，但定義距離為兩類(lèi)之間數(shù)據(jù)的最大距離。 完全連鎖 (plete linkage)，又稱(chēng)最遠(yuǎn)鄰 (furthest neightbour)方法。 ? 單原子離子，小分子到蛋白質(zhì)、核酸和其他大分子
環(huán)評(píng)公示相關(guān)推薦
鄂ICP備17016276號(hào)-1