bridion174-sugammadex-文庫(kù)吧在線文庫(kù)
【正文】 oncentration gradient favors movement of NMB agent away from the neuromuscular junction Bridion174。18:99 ? Purpose: Comparing the efficacy of sugammadex with neostigmine given with glycopyrrolate or atropine in antagonizing block produced by aminosteroidal NMBAs ? Design: ? Randomized, singledose, activecontrolled, safetyassessor blinded trial of 98 patients ? Sugammadex μg/kg plus glycopyrrolate 10 μg/kg were administered intravenously in randomized order Blobner M, et al. Eur J Anaesthesiol. 2020。g/kg). Eur J Anaesthesiol 2020。18:99. Bridion174。 Sugammadex Adverse Effects ? Side effects are dosedependent ? Common (24 mg/kg) {16 mg/kg} [placebo]: ? Nausea (23%) {26%} [23%] ? Vomiting (11%) {15%} [10%] ? Serious (24 mg/kg) {16 mg/kg} [placebo]: ? Prolonged QT interval (1%) {6%} [1%] ? Bradycardia (1%) {5%} [1%] ? Hypotension (4%) {13%} [4%] ? Anaphylaxis (0%) {1%} [0%] Bridion174。 Sugammadex Clinical Application ? Contraindications: ? Hypersensitivity to sugammadex or any ponent of the product ? Precautions: ? Use not remended with severe renal impairment or dialysisdependent
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