hp診治進(jìn)展ppt課件(存儲版)
【正文】 Cell Communication and Signaling 2022,9:28 Disruption of Epithelial cell junctionbased barrier TLR, NOD, and the NF?B signaling patrway Regulation of cell cycle progression Signaling cascades that regulate the intrinsic and extrinsic pathway of apoptosis Progression to gastric adenocarcinoma induced by infection HCO3－粘液屏障 H＋ 反彌散 致密連接破壞 離子交換紊亂 上皮細(xì)胞損傷粘液分泌減少 損害因素 尿素酶 NH3 阻斷胃酸對胃泌素分泌反饋抑制 G細(xì)胞敏感性增強(qiáng) 炎癥直接刺激 CCK對 G細(xì)胞分泌反饋抑制障礙。 ? 球形變結(jié)構(gòu)改變：球形 Hp缺乏完整細(xì)胞結(jié)構(gòu)，菌體表面分泌多聚糖，形成一層黏液樣生物膜，彼此黏附；球形變 Hp DNA指紋圖譜不變。 neutrophilactivating protein (NAP) Helicobacter pylori and obesity H. pylori infection leads to chronic active gastritis H. pylori infection leads to a decrease in circulating ghrelin and to an increase in gastric leptin Helicobacter pylori and GERD Thank you for your attention 。Advance in H. Pylori infection 同濟(jì)醫(yī)院消化內(nèi)科 王志榮 Barry Marshall and Dr Robin Warren 2022 Nobel Winners H. pylori Epidemiology of H. pylori infection 1997年 : Tomb等完成了代碼為 26695和 J99 Hp基因組全序列測定分析 ?全基因組大小分別為 1 667 867個和 1 643 831個 bp ?分別包含有 1552個和 1495個編碼蛋白的開放閱讀框(orf) ,編碼區(qū)分別占全基因組
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