現(xiàn)代脂質(zhì)三聯(lián)治療ppt課件(存儲版)
【正文】 Triad What the NCEP * Guidelines Say HDL Cholesterol ? 35 mg/dl ( mmol/l) LDL Cholesterol ? 100 mg/dl ( mmol/l) TG ? 200 mg/dl ( mmol/l) * National Cholesterol Education Program targets for secondary prevention The LDL/HDL Ratio What the Guidelines say Secondary Prevention Guidelines NCEP (USA) LDL/HDL Association of Cardiology (Germany) LDL/HDL Society of Lipid Therapy (Germany) LDL/HDL 3 Cerivastatin Clinical Data Part VI Change in LDL/HDL Ratio Datapool analysis, 8 weeks 0 1 2 3 4 5 Baseline n = 459 n = 636 n = 645 n = 1072 n = 732 LDL/HDL Ratio Data on file 50 45 40 35 30 25 20 15 10 5 0 % Change in LDL/HDL Ratio Datapool analysis, 8 weeks % Change in LDL/HDL Ratio Placebo Data on file Baseline LDL/HDL ratio After 8 weeks % of respondents ? 5 ? 5 ? 3 ? = 3 ? 3 ? = 5 ? 5 ? 3 ? = 3 ? = 3 ? 3 ? = 3 LDL/HDL Responder Rates mg responder rate at 8 weeks (n = 941) Data on file Baseline after 8 weeks 5 High CHD risk Medium CHD risk Low CHD risk 8% 60% 32% 90% 9% 1% 35 3 LDL / HDL Moving patients into the safety area after 8 weeks (n = 187) Reaching Target with LDL/HDL Ratio Reduction OSE et al. Curr Med Res amp。 Lipid Metabolism Disorders and CHD。 85: 3745 AFCAPS/TEXCAPS Apo B/A1 Tertiles LDLC/HDLC Tertiles 1 0 1 0 Event Rate per 100 PatientYears of Risk Event Rate per 100 PatientYears of Risk ? ? ? ??.4101 GOTTO A et al. Circulation 2022。 PEDERSEN T (unpublished) HDL Intervention Trial (VAHIT) RUBINS HB et al. New Engl J Med 1999。 70: 733737 Incidence of CAD vs LDL/HDL ratio by TG level (n = 4559) PROCAM Heart Study 0 50 100 150 200 250 300 3 4 5 5 6 7 LDL/HDL ratio CHD Incidence/1000 in 6 years CHD risk according to LDL/HDL ratio at baseline ASSMANN G。 MMV Medizin Verlag, 1993: 59
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