absorptivekineticsoftransdermalfentanyl：芬太尼透皮吸收動力學(存儲版)
【正文】 icity TTSfentanyl Pharmacokiics Kiics ? Absorption – F = – Protein binding = 79 97% – Tmax = 35 hours ? Distribution – Vd = 3 – 8 L/kg ? Metabolism – CYP3A4 – Major: norfentanyl – Minor: hydroxyfentanyl, hydroxynorfentanyl, despropionylfentanyl Kiics Kiics ? Elimination – Cl = – – T1/2 = 17hrs (after removal) Study ? Solassol I, Caumette L, Bressolle F, et al. “Inter and intraindividual variation in transdermal fentanyl absorption in cancer pain patients.” On
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