分子生物學(xué)43592842-免費(fèi)閱讀
【正文】 LRRC4, a Putative Tumor Suppressor Gene, Requires a Functional Leucinerich Repeat Cassette Domain to Inhibit Proliferation of Glioma Cells In Vitro by Modulating theExtracellular Signalregulated Kinase/Protein Kinase B/Nuclear FactorκB PathwayMolecular Biology of the CellVol. 17, 3534–3542, August 2023Guiyuan Li et al. 0711078 曹廣超LRRC4 gene which contains a conserved leucinerich repeat (LRR) cassette and an immunoglobulin (Ig) IgC2 domain, is associated with glioma suppression both in vitro and in vivo. The present study provides evidence that the conspicuous absence of LRRC4 in highgrade gliomas directly contributes to the increasing tumor grade. The loss of LRRC4 in U251 cells is caused by the loss of h
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