分子生物學(xué)43592842(文件)
【正文】 the core LRR is found to be indispensable for the function of LRRC4.? The inhibitory effect of LRRC4 is acpanied by a decrease in the expression of pERK, pAkt, pNFBp65, signal transducer and activator of transcription protein3 (STAT3), and mutant p53, and an increase in the expression of cJun NH2terminal kinase (JNK)2 and pcJun, suggesting that LRRC4 plays a major role in suppressing U251 cell proliferation by regulating the extracellular signalregulated kinase (ERK)/Akt/NFBp65, STAT3, and JNK2/cJun pathways. ? Tumor Samples and Cell Lines? Nucleic Acid Isolation and RNA Analysis? OneStep PCR Mutagenesis and Constructs? Western Blotting Analysis? Cell Proliferation Assay? Soft Agar Assay? Cell Cycle Analysis? Acridi
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