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Infection an Colonization ? Chronic gastritis ? Peptic ulcer ? Gastric adenocarcinoma ? MALT lymphoma ? gastroesophageal reflux disease? ? functional dyspepsia? ? idiopathic thrombocytopenic purpura ? irondeficiency anemia H. pylorirelated diseases ? Hp損害胃黏膜屏障 ? Hp誘導(dǎo)炎癥和免疫反應(yīng) ? Hp基因片斷整合到宿主細(xì)胞 DNA ? 影響胃酸的分泌 Hp致病機(jī)制 ? CagA (cytotoxin associated protein ? VacA (vacuolating cytotoxin) ? SabA(sialicacidbinding adhesin) BabA(Blood group antigenbinding adhesion ) ? OipA (outer inflammatory protein A) ? Interfernce of microRNA expression ? Ammonia, lipopolysaccharide, inflammatory mediator ? Phosphatase A, urease virulence factors Overview of H. pylori factors that interfere with host cell functions Wroblewski LE, et al., Targeted disruption of the epithelialbarrier by H. pylori. Cell Communication and Signaling 2022,9:29 Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Backert S,et al., Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by H. pylori.