生物技術(shù)藥物,12。stemcell-免費(fèi)閱讀
【正文】 裴雪濤，軍事醫(yī)學(xué)科學(xué)院 3。 ?中科院干細(xì)胞生物學(xué)重點(diǎn)實(shí)驗(yàn)室。 干細(xì)胞生物技術(shù)在美國(guó)的現(xiàn)狀 美國(guó)前 10名大學(xué) 美元（萬(wàn)） 哈佛大學(xué) 10000 斯坦福大學(xué) 1200 加州大學(xué) 500 康州大學(xué) 1000 華盛頓大學(xué) 500 普林斯頓大學(xué) 600 哥倫比亞大學(xué) 800 耶魯大學(xué) 威斯康辛大學(xué) 賓西法尼亞大學(xué) 芝加哥大學(xué) 干細(xì)胞研究中心 干細(xì)胞研究所 干細(xì)胞興趣小組 干細(xì)胞沙龍 中國(guó)在干細(xì)胞生物技術(shù)領(lǐng)域的優(yōu)勢(shì) ?寬松的社會(huì)環(huán)境，不同的倫理觀念。 basic biology. Why are Stem cells important? ? Ability to develop into virtually any other cell made by human body. ? In theory, if stem cells are grown they could be of significant medical importance to grow bone marrow, neural tissue or muscle to treat Disease. ? Parkinson’s*, Alzheimer’s, Diabetes, Heart Disease, Stroke, Down syndrome, Spinal Cord injuries and Burns. Two Kinds of Stem Cells Embryonic (also called “pluripotent”) stem cells are capable of developing into all the cell types of the body. Adult stem cells are less versatile and more difficult to identify, isolate, and purify. What are Embryonic Stem Cells? ? Undifferentiated cells with the ability to form any adult cell. They can proliferate indefinitely in culture amp。 Regenerative Medicine Transgenic Animals Transgenic Animals Outline ? Why develop transgenic animals? ? How are heterologous genes introduced and expressed in animal systems? ? Can animals be cloned? ? What is the current technology in animal transgenesis? ? What are the applications of transgenic animal technology? Transgenic Animals Why? ? Selective breeding has been used over many generations to geically improve animals for desirable traits ? Breeding pure lines is timeconsuming and costly ? Introduction of a new trait into a pure breeding line is difficult ? Limited by naturally occurring traits Transgenic Animal Applications ? Geic engineering of desirable traits ? Rapid creation of pure breeding lines and identical offspring (clones) ? Animal model systems for research in human diseases ? Animal systems as bioreactors for production of heterologous biological molecules (“pharming”) How to Introduce Foreign Genes Basic Strategy ? Inject a cloned gene into the nucleus of a fertilized egg ? Implant the geically engineered egg into a receptive female ? Screen for animals with the gene integrated into their germ line cells ? Selective b
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