【新整理】利用生物標志物患者急性心血管疾病-預(yù)覽頁
【正文】 144.9) Antman, 1996 3.8 (1.88.03),Individual Studies of Patients with“Unstable Angina” Without ST Segment Elevation,Peto OR amp。 Laboratory Medicine Professor of Medicine Mayo Clinic and Medical School Rochester, Minnesota,*Dr. Jaffe is a consultant and receives research support from Roche, Dade Behring and Beckmann Coulter. He has been or presently is a consultant to Ortho Diagnostics, Sensera, Diadexus, Abbott, Hawaii Biotech and Tartagen.,CP10518121,Clinical Outcomes by Braunwald Class,Days,Days,Primary Unstable Angina Class B,Postinfarction Angina Class C,Accelerated Angina Class I,Subacute Angina at Rest Class II,Acute Angina at Rest Class III,P,P,0.97,0.91,0.53,0.96,0.88,0.72,0.94,0.86,0.35,0.97,0.89,0.55,0.89,0.80,0.37,JACC 25:1286, 1995,ECG Risk Factors in Patients with ACS,Death or MI (%),Days,JACC 36(3):9701062, 2000,ST elevation and depression,ST depression only,ST elevation only,Twave inversion only,No ST or Twave change,n=237,n=287,n=93,n=216,n=78,CP95602412,Relationship of ECG Changes and FPA*,FPA (nM),*JACC 18:898903, 1991,,nl 1.5,LongTerm Prognostic Value of Elevated cTnI in Unstable Angina,% free from death and/or AMI,Time from admission (days),Normal cTnI,Log rank 6.63, P=0.01,Elevated cTnI,Circulation. 1997。,Synergism of ECG and Elevated Troponins (PARAGON),CP10995008,JACC 41:376, 2003,6mo death/ MI rate,n=262,STdepression,P=0.20,n=125,n=259,n=174,n=57,n=82,P=0.13,P=0.15,FRISCII – GUSTO IV (Death and MI),CP114235617,James et al: Am J Med 115:181, 2003,14 12 10 8 6 4 2 0,0.01 181。g/L,GUSTOIV,0.03 181。 1.302.54,1.82。 1.792.85,1.47。g/L) CKMB (3.5 181。g/L) TnI (0.07 181。 31,BNP Levels of Patients Diagnosed Without CHF, with Baseline Left Ventricular Dysfunction, and with CHF,BNP Levels in Heart Failure,Median BNP level (pg/mL),CP118945226,BNP Levels in Normal Subjects and Inpatients with Heart Failure,Normal,I,II,III,IV,Class,CP118945227,ED Probability of CHF Recorded,P0.0001 from clinical judgment to combined,McCullough PA et al: Circulation 106:416, 2002,Diagnostic accuracy (%),Clinical judgment,BNP,Combined,70 72 74 76 78 80 82,74.0,81.2,81.5,n=1,538,BNP Study Primary End Point,n=1,586。17
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