《hp診治進(jìn)展》ppt課件-預(yù)覽頁
【正文】 group antigenbinding adhesion ) ? OipA (outer inflammatory protein A) ? Interfernce of microRNA expression ? Ammonia, lipopolysaccharide, inflammatory mediator ? Phosphatase A, urease virulence factors Overview of H. pylori factors that interfere with host cell functions Wroblewski LE, et al., Targeted disruption of the epithelialbarrier by H. pylori. Cell Communication and Signaling 2022,9:29 Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Backert S,et al., Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by H. pylori. Cell Communication and Signaling 2022,9:28 Disruption of Epithelial cell junctionbased barrier TLR, NOD, and the NF?B signaling patrway Regulation of cell cycle progression Signaling cascades that regulate the intrinsic and extrinsic pathway of apoptosis Progression to gastric adenocarcinoma induced by infection HCO3－粘液屏障 H＋ 反彌散 致密連接破壞 離子交換紊亂 上皮細(xì)胞損傷粘液分泌減少 損害因素 尿素酶 NH3 阻斷胃酸對胃泌素分泌反饋抑制 G細(xì)胞敏感性增強(qiáng) 炎癥直接刺激 CCK對 G細(xì)胞分泌反饋抑制
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