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than DM, et al. Diabetologia 2006。,通常(tōngch225。,一種OHA基礎(chǔ)(jīchǔ)上加用基礎(chǔ)(jīchǔ)胰島素是最有效的,診斷(zhěndu224。,第二十三頁(yè),共五十三頁(yè)。ngch225。,DPP research group,N Engl J Med 2002。,DPP:平均(p237。)血糖變化,DPP research group,N Engl J Med 2002。,ADA/EASD: 2型糖尿病的治療(zh236。ntǒng)的階梯遞序方案導(dǎo)致治療時(shí)機(jī)的延遲,即使加以(jiāyǐ)治療,在歐洲和美國(guó)仍分別有61%和63%的患者達(dá)不到推薦的HbA1c目標(biāo)1,2,1. Liebl A, et al. Diabetologia 2002。o)要求,避免(b236。o)針對(duì)β細(xì)胞功能缺陷和胰島素作用障礙兩個(gè)方面,Torrens JI, et al. Diabetes Care. 2004 Feb。ng)障礙,改善(gǎish224。)是血糖異常的關(guān)鍵,Eleuterio Ferrannini,MD. impaired betacell function, in 66th ADA,2006,不發(fā)生(fāshēng)T2DM,β細(xì)胞(x236。,Diabetes Research and Clinical Practice (2005) S22–S29,2型糖尿病的發(fā)病(fā b236。o),單藥,兩種藥物聯(lián)合應(yīng)用,三種或以上藥物聯(lián)合,二種OHA控制血糖無(wú)效 使用胰島素,data from TNS2006,其它,任何OHA聯(lián)合應(yīng)用無(wú)法控制血糖,使用胰島素,23,50,27,0,20,40,60,80,100,Monomedication,Two medication combined,Three or above medication combinated,76,20,4,0,20,40,60,80,100,Others,Use insulin when any combined usage of OHA are ineffective to control,blood glucose,Use insulin when two OHA are ineffective to control blood glucose,第十頁(yè),共五十三頁(yè)。)OHA治療的現(xiàn)狀,%,%,胰島素治療(zh236。,0,10,20,30,40,50,60,70,80,Individuals achieving treatment goals (%),HbA1c 6.5%,Total cholesterol 175 mg/dL,Triglycerides 150 mg/dL,Systolic BP 130 mmHg,Diastolic BP 80 mmHg,15%,72%,46%,72%,58%,相對(duì)于血脂、血壓(xu232。),內(nèi)分泌學(xué)分冊(cè), May 2005, Vol 25,(3): 1748,中國(guó)糖尿病患者血糖控制(k242。t225。,UKPDS 35. BMJ 2000。ngbi224。ngbi224。r)血糖 (mmol/L),7.0,7.8 11.1,Combined Hyperglycemia,IIGT,6.1,5.6,糖尿病前期(qi225。i):百萬(wàn),我國(guó)目前有4000萬(wàn)糖尿病患者 2015年患病率超過(guò)10%,患者數(shù)超過(guò)1億 目前每天新增病例3000人,第二頁(yè),共五十三頁(yè)。)21世紀(jì)的流行病,Zimmet P et al. Diabet Med. 2003。糖尿病干預(yù)(gāny249。nqi)將達(dá)3.24億 增長(zhǎng)72%,單位(dānw232。n),IFHIsolated Fasting Hyperglycemia,CH,IIFG Isolated Impaired Fasting Glucose,IFG+IGT,IPH Isolated Post Challenge Hyper glycemia,Isolat