immunity免疫-全文預(yù)覽
【正文】 5 classes of Ab in mammals each has a different class of heavy chain IgM, IgD, IgG, IgA, IgE The diversity of antigen binding domains is dependent on the variable regions of the light and heavy chains Light and heavy chains are posed of repeating segments that fold independently to form functional units called immunoglobulin (Ig) domains Organization of the DNA sequences that encode the constant regions of an Ab heavy chain Generation of Antibody Diversity At rest or in the absence of pathogen assault, the immune system can likely make 1012 different antibodies How can an animal make more Antibodies than there are genes in the genome? Answer lies in the variable regions of the antigen binding site on Antibodies. Eg if have 1000 different light chains and 1000 different heavy chain genes 1000 x 1000 = 1,000,000 different antigen binding sites Antibody Diversification Rearrangement of DNA during B cell development Site specific rebination is involved in generating Ab light chain diversity Adaptive Immune System Functions are performed by white blood cells (Lymphocytes) 2 classes of responses Antibody Responses (Bcells responses) Cellmediated Responses (Tcell responses) Similarities and Differences between Tcell and Bcell responses Similarities Highly Antigen specific Differenc
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