哈爾濱醫(yī)科大學(xué)神經(jīng)病學(xué)中樞神經(jīng)系統(tǒng)脫髓鞘疾病-全文預(yù)覽
【正文】 quired. 預(yù)后分型 緩解 Examples 患者，女， 32歲。 ② Suppression or modulationof the immune system: IFN?1? and 1b 。 2. 盡量預(yù)防能促發(fā)的外因，減少復(fù)發(fā)次 數(shù)，延長(zhǎng)緩解間歇期。 CSF OB/IgG。 3. Clinical probable MS (CPMS): ① two attacks, one lesion 。 ② two attacks, one lesion and one subclinical evidence。 ③ somatosensory evoked potentials(SEP). 3) MRI : ① preiventricular plaques。 oligoclonal bands(OB) (95%)。 ⑥ Impairment of PNS。 ② The visual loss in one or both eyes。 肉眼觀： CNS內(nèi)脫髓鞘斑塊 5. Clinical Manifestations 1) Prodrome: The symptoms evolved more slowly, over several weeks or months. 2) Acute or subacute onset (Relapsing remitting). 3) Early symptoms and signs: ① Weakness or numbness。 ③ A relative integrity of the axis cylinders in the lesions and a lack of wallerian, the secondary degeneration of fiber tracts. 臨床常見脫髓鞘疾病 急性播散性腦脊髓炎 (acute disseminated encephalomyelitis, ADEM ) 多發(fā)性硬化癥 (multiple sclerosis, MS) 亞型視神經(jīng)脊髓炎 ( Devic diseases ) 急性出血性白質(zhì)腦病 (acute hemorrhage leukoencephalitis, AHLE) 多發(fā)性硬化癥 (MS) 多發(fā)性硬化 Multiple Sclerosis,MS 1. Concept: Ms is a kind of autoimmune diseases characterized by demyelination of CNS. Due to its high incidence, chronicity and tendency to attack young adults, it has bee one of the most important CNS diseases. There are multiple areas of demyelination within the episodes of demyelination are separated in time and place,and classically the disease runs a relapsingremitting course. (brain and spinal cord) 是一種常見以中 樞神經(jīng)系統(tǒng)炎性 脫髓鞘為特征的 自身免疫性疾病 病灶部位及時(shí)間上的多發(fā)性 多數(shù)均以反復(fù)多次發(fā) 作與緩解的病程 具有免疫易感性、 年輕人多見 2. Etiology And Pathogenesis 1) 病毒感染及自身免疫反應(yīng)： Since the exact cause is uncertain. Immunological mechanisms un
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