中國(guó)醫(yī)科大學(xué)附屬一院風(fēng)濕免疫科張 榕【精選-全文預(yù)覽
【正文】 系統(tǒng)性紅斑狼瘡 Etiology geic factors environmental factors Sex hormonal factors 系統(tǒng)性紅斑狼瘡 Pathogenesis Excessive, abnormal production of “self” antibodies and formation of IC. Autoantibodies against nuclear, cytoplasmic and membrane ponents of multiple cell types in multiple ans . 系統(tǒng)性紅斑狼瘡 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 系統(tǒng)性紅斑狼瘡 Pathology 光鏡 : 特征性 :疣狀心內(nèi)膜炎 蘇木紫小體 “ 洋蔥皮樣 ” 病變 臨床應(yīng)用：皮膚狼瘡帶試驗(yàn) 腎活檢 系統(tǒng)性紅斑狼瘡 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 系統(tǒng)性紅斑狼瘡 系統(tǒng)性紅斑狼瘡系統(tǒng)性紅斑狼瘡 Systemic features Fever Weak Weight loss 系統(tǒng)性紅斑狼瘡 skin and mucosa 光敏感 photosensitivity 脫發(fā) alopecia 雷諾現(xiàn)象 Raynaud’s phenomenon 口腔潰瘍 oral ulcer 皮疹 rash 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 Muscle and Joint arthritis Jaccoud’s arthropathy Muscle pain、 myositis femoral head necrosis 系統(tǒng)性紅斑狼瘡 Muscle and Joint 系統(tǒng)性紅斑狼瘡 Renal lesion Proteinuria hematuria cylindruria Nephritic syndrome Renal insufficiency 系統(tǒng)性紅斑狼瘡 lupus nephritis Class I 正常 Class II 系膜增殖性 mesangial Class III 局灶增殖性 focal proliferative Class IV 彌漫增殖性 diffuse proliferative Class V 膜性 membranous Class VI 腎小球硬化性 glomerulosclerosis 系統(tǒng)性紅斑狼瘡 Nervous system clinical manifestation: headache、 vomiting psychogenia epilepsy convulsion 、 conscious disturbance a pathologyvasculitis cerebrospinal fluidno special (intracranial pressure↑protein↑c(diǎn)ell population↑ glucose↓) Identify with other central nervous system disease 系統(tǒng)性紅斑狼瘡 Hematology system leukopenia thrombocytopenia anemias: hemolytic anemias anemias of chronic disease lymphadenectasis splenectasis 系統(tǒng)性紅斑狼瘡 Respiratory system pleurisy Pleural effusion Pulmonary interstitial fibrosis Lupus pneumonia Pulmonary hypertension Respiratory failure 系統(tǒng)性紅斑狼瘡 lung 系統(tǒng)性紅斑狼瘡 Circulatory system heart pericarditis myocarditis endocarditis LibmanSack endocarditis cardiac arrhythmias cardiac failure vessel vasculitis 系統(tǒng)性紅斑狼瘡 Digestive system Clinical features anepithymia nausea and vomiting abdominal pain、 diarrhea peritoneal effusion acute abdomen pathology mesenterium vasculitis 系統(tǒng)性紅斑狼瘡 抗磷脂抗體綜合征 (antiphospholipid antibody syndrome) clinical manifestation: arterous and/or venous thrombosis
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