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90 mmHg Addition of Felodipine 510 mg if SeDBP ? 90 mmHg Double blind Irbesartan and atenolol in hypertension and LVH: SILVHIA study design 4 0 12 24 48 Week * * * * Malmqvist K, Kahan T et al. Am J Cardiol 2020:90。33:713 來(lái)自 下載 伊貝沙坦與氨氯地平改善 QT離散 QT 離散 (ms) QTc 離散 (ms) QTc max(ms) ? P= ? P= ? P= ? P= ? P= ? P= Irbesartan Amlodipine (n=53) (n=51) 來(lái)自 下載 Irbesartan and atenolol in hypertension and LVH: Effects on QT dispersion Irb: p Ate: p = Irb vs Ate: p = Irb: p Ate: p = Irb vs Ate: p = 60 40 ms 60 40 ms 0 12 48 Weeks 0 12 48 0 12 48 Weeks 0 12 48 Irbesartan Atenolol Malmqvist K et al. Am J Cardiol 2020:90。106:3316. 來(lái)自 下載 Irbesartan significantly increased probability of maintaining sinus rhythm 0 20 40 60 80 100 % probability of maintaining sinus rhythm Irbesartan + amiodarone Madrid A et al. Circulation 2020。 。已有證據(jù)顯示,血管緊張素 Ⅱ 受體拮抗劑伊貝沙坦能有效逆轉(zhuǎn)左心室肥厚,改善 QT離散度,阻止心房電重構(gòu),減少持續(xù)心房顫動(dòng)患者電復(fù)律後心房顫動(dòng)復(fù)發(fā)率。106:331 來(lái)自 下載 在慢性持續(xù)性心房顫動(dòng)患者,前瞻性、隨機(jī)觀察伊貝沙坦對(duì)電復(fù)律後維持竇性心律的療效。116776. 來(lái)自 下載 Irbesartan vs. atenolol in hypertension and LVH: LVMI reduction Irb vs. Ate p =