【正文】 s with a ~ /d vitamin D intake. The effects of higher doses were greatly different. For example, among 63 aged persons (the female was more than 60 years old, the male more than 65 years old) provided with a replenishing dose of /d vitamin D (unspecified dose) for 6 months, two persons developed hypercalcinemia (Johnson et al, 1980). However, in another study lasted for five months, 61 adults (the average age was 41 years old) were given a replenishing dose of /d vitamin D3, and their serum calcium level did not increase significantly (Vieth et al, 2001). This difference may reflect that the aged has developed hyperparathyroidism or vitamin D deficiency before the intervention.17. Clinical dataVitamin AA few hundred years ago, Night blindness and xerophthalmia were associated with the incidence and mortality of infectious disease. In 1930s, vitamin A as an antiinfective vitamin has been widely researched and applied. With a lack of vitamin A, the way to constitute ligand of nuclear receptor is changed in different tissues, and the damage of immune function at multiple levels is shown. As for mucosal immunity, vitamin A deficiency not only damages the integrity of mucosal epithelia of eyes, respiratory tract, gastrointestinal tract and genitourinary tract, but also lowers the local secretion of IgA. In recent years, clinical and human population tests have shown that for infants supplemented with vitamin A, incidence and mortality of diseases of various causes could be significantly reduced.1. Child viral infection Vitamin A has been tested in different kinds of child viral infectious diseases, such as measles, respiratory syncytial virus, chicken pox and AIDS. Twelve researches have shown that Vitamin A could prevent children with above diseases from death, and therefore it should be widely used. It is reported that low level of serum vitamin A was related to predisposition of child pneumonia, diarrhea and other diseases, and supplement of VA can prevent infectious diseases in digestive tract, respiratory tract and could be used as an auxiliary therapy for these infectious diseases. 2. DiabetesDiabetics are prone to vitamin A shortage. It was reported that Vitamin A supplement could improve the blood glucose control of diabetics. Diabetics should decide whether they would take additional vitamin A preparations based on the medical advice 3. Skin diseasesVitamin A has been tested in various kinds of skin diseases, including ae, psoriasis, brandy nose, seborrheic dermatitis, eczema, but the curative effect was not so noticeable. In general, the does close to the poisoning dose may obtain a good curative effect.4. MenorrhagiaIt was reported that for the female with menorrhagia, the amount of menstrual flow may be reduced through daily intake of 25000IU vitamin A. It could not be used as a longterm therapy, because once amenorrheic women were pregnant, highdose vitamin A may lead to fetal anomaly.5. AIDSIt’s reported that the intake of higherdose of vitamin A for 6 ~ 8 years may be beneficial for patients with AIDS, but if the intake is over 20268IU/d, the effect to reduce risks and mortality of AIDS will be decreased instead.6. Iron deficiency anemiaRecent studies have found that diet short of vitamin A and iron could also lead to iron deficiency anemia. Population intervention trials also confirm that the supplementation of single vitamin A or iron may improve anemia, but the jointed supplementation of vitamin A and iron may gain the best effect.7. Palpebral conjunctiva and keratonosusVitamin A may maintain the normal differentiation and integrity of corneal and conjunctival epithelial cells, and it has been widely applied clinically. Recently, In China someone treated the keratopathy with vitamin A eye drops and achieved satisfactory therapeutic effect.Vitamin D1. RicketsIt has been reported that the demand of vitamin D would be increased relatively for infants because of their rapid physical growth (Wu Guangchi, 1989。 meanwhile 1636 women in the control group were given placebos (Chapuy et al, 1992). The results showed that bone density in the group supplemented with VD and calcium was increased by %, meanwhile it was reduced by % in the control group (P ). Compared with the control group, the number of cases with hipbone fracture in the group supplemented with VD and calcium was reduced by 43% (P = ), and the total number of cases with nonvertebral fractures was reduced by 32% (P = ).3. OsteomalaciaIt was reported that offering 400IU/d vitamin D to pregnant women could reduce the incidence of maternal osteomalacia, neonatal hypocalcemia and te