【正文】
基于 CAPRIE卒中亞組開(kāi)發(fā)的卒中預(yù)測(cè)模型 2021/6/15 15 ESSEN評(píng)分:預(yù)測(cè)卒中復(fù)發(fā)或嚴(yán)重血管事件的風(fēng)險(xiǎn) REACH登 記 研究 68,236名患者 “結(jié) 果 顯 示: ESRS可以 預(yù)測(cè)處 于 穩(wěn) 定期的卒中 門診 和住院患者 發(fā) 生卒中和復(fù)合CV事件 (CV死亡、心梗、卒中 )的 風(fēng)險(xiǎn) ” CV = 心血管 。40:350354 2021/6/15 17 Christian Weimar, et al. The Essen Stroke Risk Score Predicts Recurrent Cardiovascular Events. Stroke, 2021, 40:350354. REACH:ESSEN評(píng)分越高, 卒中和復(fù)合心血管事件發(fā)生率越高 REACH研究入選 15,605例病情穩(wěn)定的缺血性卒中 /TIA門診患者 (排除房顫患者 ),隨訪 1年 無(wú)論住院或門診患者, ESSEN評(píng)分有助于識(shí)別高?;颊?,評(píng)估卒中患者再發(fā)風(fēng)險(xiǎn) ★ ★ 卒中 復(fù)合心血管事件 0 1 2 3 4 5 6 6 ESSEN ESSEN3 30% ESSEN≥3 70% 事件率/年% 2021/6/15 18 SCALA: 近 60%的患者處于高復(fù)發(fā)風(fēng)險(xiǎn) Weimar C. Rother J. et al. J Neurol, 2021, 254 (11).15621568 Essen卒中風(fēng)險(xiǎn)評(píng)分 0 1 2 3 4 5 6 7 8 9 高危 % 低危 % 患者(%) 16 0 20 30 ?SCALA研究(前瞻性觀察隊(duì)列), 85家卒中單元,德國(guó), 852例,急性缺血性卒中 /TIA,不予干預(yù),平均隨訪 2021/6/15 19 ESSEN評(píng)分的應(yīng)用 9 8 7 6 5 4 3 2 1 0 高危,卒中風(fēng)險(xiǎn) ≥4% 中危,卒中風(fēng)險(xiǎn) 4% 氯吡 格雷75mg/d 阿司匹林 50325 mg/d 2021/6/15 20 AHA卒中二級(jí)預(yù)防指南 顱內(nèi)大動(dòng)脈狹窄 50%~99% ? For patients with stroke or TIA due to 50% to 99% stenosis of a major intracranial artery, aspirin is remended in preference to warfarin (Class I。( I, B) ? For patients with stroke or TIA due to 50% to 99% stenosis of a major intracranial artery, longterm maintenance of BP 140/90 mm Hg and total cholesterol level 200 mg/dL may be reasonable (Class IIb。 Level of Evidence A). ? 頸動(dòng)脈重度狹窄( 70%~99%)且過(guò)去的 6個(gè)月內(nèi)造成缺血性卒中或 TIA,如圍手術(shù)期死亡風(fēng)險(xiǎn)低于 6%推薦 CEA( I, A) ? For patients with recent TIA or ischemic stroke and ipsilateral moderate (50% to 69%) carotid stenosis, CEA is remended depending on patientspecific factors, such as age, sex, and orbidities , if the perioperative morbidity and mortality risk is estimated to be 6% (Class I。 B) ? CAS is indicated as an alternative to CEA for symptomatic patients at average or low risk of plications associated with endovascular intervention when the diameter of