信號分子與信號轉(zhuǎn)導(dǎo)signalingtransdu-wenkub
2023-05-11 13:51:32 本頁面
【正文】 logy 2 domain: SH2 domian ? Function: the recognized motif is phosphorylated tyrosine and neighboring amino acids ? Different protein contains different SH2 selectivity 3. SH3 Domain ? Src homology 2 domain: SH3 domian ? Function: the recognized motif is prolinerich (910 Pro) sequence 4. PH Domain recognizes the phospholipids ? PH domain in pleckstrin in platelet， so called pleckstrin homology ? PH binding with membrane PL derivative，make its localization to membrane, enzyme activity increase ? PH is a basic structure of protprot, protlipid interaction Ⅲ . adaptor proteins and scaffolding proteins ? adaptor protein a kind of mediator protein, Link one, upstream prot., to another, downstream ? role： recruit and anize the plex ? Most adaptor proteins contain two domains, no other special domain 1. adaptor protein Adaptor protein Nck SH2 C N SH3 SH3 SH3 HGFR, VEGFR, BCRAbl PDGFR, EphB1 SLP76, HPK1, p130cas IRS1,p62doc CKIg2,WASP,IRS1, DOCK180, NIK IRS1,DOCK180, Sos, NIK,Pak1,Pak3,NAP4,WIP,dynamin, synaptojanin、 Abl,cCbl Abl,cCbl,NAP1,Sam68 Sumaary of Section 4 1. Signaling plex exists at membrane and cytoskeleton structure. Within plex the special domain in a protein is a base of interacting with others. 1. Adaptor proteins and scaffolding proteins are the linker molecules in signaling and work. Section 5 General Signal Pathways Mediated by Membrane Receptors 膜受體介導(dǎo)的基本信號轉(zhuǎn)導(dǎo)通路 ? 3 types of membrane bound receptor： ?Ion channel receptor (ICR) ?Gprotein coupling receptor (GPCR) ?Single transmembrane receptor (STMR) ICR GPCR STMR 內(nèi)源性配體 神經(jīng)遞質(zhì) 神經(jīng)遞質(zhì)、激素、趨化因子、外源刺激（味，光） 生長因子 細(xì)胞因子 結(jié)構(gòu) 寡聚體形成的孔道 單體 具有或不具有催化活性的單體 跨膜區(qū)段數(shù)目 4個 7個 1個 功能 離子通道 激活 G蛋白 激活蛋白酪氨酸激酶 細(xì)胞 應(yīng)答 去極化與超極化 去極化與超極化調(diào)節(jié)蛋白質(zhì)功能和表達(dá)水平 調(diào)節(jié)蛋白質(zhì)的功能和表達(dá)水平，調(diào)節(jié)細(xì)胞分化和增殖 Characters of 3 types receptors Ⅰ . Ion Channel
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