理學(xué)生理學(xué)ppt課件-wenkub
2023-01-18 00:42:15 本頁面
【正文】 , denied this view. ? Welsh used shortcircuit current method to do this article. 短路電流裝置 ? 短路電流 (ISC) 定義為穿過上皮并使得跨上皮電壓降為零的電流。Human cystic fibrosis airway epithelia have reduced Cl? conductance but not increased Na+ conductance Omar ,1, JengHuar Chena,b, Philip H. Karpa,b, Sarah Ernsta, Shaf Keshavjeec, Kalpaj Parekhd, Julia KlesneyTaita, Joseph Zabnera,2,and Michael ,b,e,2 Departments of aInternal Medicine,dCardiothoracic Surgery, and eMolecular Physiology and Biophysics and bThe Howard Hughes Medical Institute, The RoyJ, and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA52242。 ? 鉗制模式 1. 電流鉗模式－跨上皮電流被鉗制在 0μA，測量細(xì)胞兩側(cè)的電勢差。 離子替代法 ? 把正常 KH溶液中的某種離子替換掉（如 Cl用葡萄糖酸根替代），看此時加藥后的反應(yīng)比起在正常 KH中的反應(yīng)是否有變化。 Cl 分泌 NKCC cotransporter CFTR Na+ channel 基底膜面 頂膜面 ? New born CFTR?/? and CFTRΔF508/ΔF508 pigs increased nasal Vt and ?Vtamil like persons who have CF. But have no more Na+ absorption than controls. ? In CF, elevatio
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