分子生物物理學(xué)(已修改)
2025-01-05 03:46 本頁(yè)面
【正文】 MolecularBiophysics分子生物物理學(xué)分子生物物理學(xué)分子水平分子水平結(jié)構(gòu)結(jié)構(gòu) 功能功能研究生物體系物理學(xué)性質(zhì)、行為研究生物體系物理學(xué)性質(zhì)、行為Biopolymers: Nucleic acid (DNA, RNA) ProteinMoleculesinBiosystemSaccharideLipidOtherPROTEINSTRUCTURE 1965年中國(guó)在世界上首次用化學(xué)方法人工合成的蛋白質(zhì) － 牛胰島素SecondaryStructurePrimaryStructureTertiaryStructuresupersecondaryStructureormotifdomainQuaternaryStructureHierarchyofProteinStructureby Linderstr248。mLangChiralLalanineCOOHCH3NH2HPropertyofaminoacidzwitterionUnchargedstructureMinorponentDipolarion,orzwitterionMajorponentClassificatoryofaminoacidbasedsidechains(Rgroups)Nonpolar G,A,V,L,I。 F,W, P,M,Polarneutral S,T, N,Qacidic D,E。 C,Y basic R,K, H?HistidineProteinPrimaryStructurePeptide bondBackboneSide chain Amine/N terminusCarboxyl/C terminus PaulingCoreyCN, C=N, ?=180? ?=180? ?=0? ?=0??CCN,C? C O N HC ()()()()O ()()()N ()()H ()MinimalDistance(197。)betweennonbondingatom()phi(?),psi(Y),andomega(W) interaction Relation with Energy and distancechargercharge r1chargerdipole r2dipoledipole r3chargeinduced dipole r4dipoleinduced dipole r6Transient dipoleinduced dipole r6Relation with Energy and distance VanderWaalsforce LennardJonespotential10kJmol1， range:～ nm Hbond definition, Hbond location O….H XHydrogenbond OH XHydrogen bonds can vary in strength from very weak (12 kJ mol?1) to extremely strong (40 kJ mol?1), so strong as to be indistinguishable from a covalent bond, as in the ion HF2?. Typical values include:O—H...:N (7 kcal/mol) O—H...:O (5 kcal/mol) N—H...:N (3 kcal/mol) N—
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