外文翻譯---激光的組織接合：激光束光斑尺寸和研究概況(已修改)
2025-01-29 23:08 本頁面
【正文】 附錄A 英文原文Laser Tissue Welding: Laser Spot Size and Beam Pro?le StudiesAbstract：This paper evaluates the effect of laser spot diameter and beam pro?le on the shape of the thermal denaturation zone produced during laser tissue welding. 2cmlong fullthickness incisions were made on the epilated backs of guinea pigs in vivo. India ink was used as an absorber and clamps were used to appose the incision edges. Welding was performed using continuouswave , Nd:YAG laser radiation scanned over the incisions to produce 100ms pulses. Laser spot diameters of 1, 2, 4, and 6 mm were studied, with powers of 1, 4, 16, and 36 W, respectively. The irradiance remained constant at 127 Monte Carlo simulations were also conducted to examine .the effect of laser spot size and beam pro?le on the distribution of photons absorbed in the tissue. The laser spot diameter was varied from 1 to 6 mm. Gaussian, ?attop, dual Gaussian, and dual ?attop beam pro?les were studied. The experimental results showed that 1, 2, 4, and 6mmdiameter spots produced thermal denaturation to an average depth of 570, 970, 1470, and 1900 m, respectively. Monte Carlo simulations demonstrated that the most uniform distribution of photon absorption is achieved using large diameter dual ?attop beams. Index Terms— Denaturation, laser biomedical applications, laser materialsprocessing applications, laser welding, Monte Carlo methods, optical propagation.MATERIALS AND METHODSA. ExperimentsIn vivo welding of skin incisions was performed at constant irradiance to investigate the effect of various laser spot sizes (1, 2, 4, and 6mmdiameter FWHM) on the extent of thermal denaturation at the weld site. Adult female albino guinea pigs (Hartley, age 7–8 weeks, weight 400–500 grams) were shaved then epilated with a chemical depilator (Nair,CarterWallace, Inc., New York, NY). Each guinea pig was anesthetized with atropine ( mg/kg), ketamine (30 mg/kg), and xylazine (2 mg/kg) administered by intraperitoneal injection. 1% lidocaine with 1:100000 epinephrine was used as a local anesthetic at each incision site. 2cmlong, fullthickness incisions were made parallel to the spine with a scalpel. Four incisions were made on the back of each guinea pig. Approximately 2–5 l of India ink (black India Rapidograph ink, 3080F, 100nm particle diameter, KohINoor, Bloomsbury, NJ) were applied to the wound edges with a micropipette. The animal was then placed prone on a translation stage, in preparation for surgery. Clamps were used to temporarily appose the incision edges during welding.Welding was performed with a continuouswave (CW), Nd:YAG laser (Lee Laser, Model 703T) emitting radiation that was coupled into a 600 core diameter optical ?ber (Thor Labs, Newton, NJ). A steppermotordriven translation stage (Newport, Irvine, CA) scanned the laser beam along the axis of the weld site at speeds that effectively produced 100mslong pulses. Seventy scans were made along each weld。 the beam stopped a
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