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Pericardial Disease Wutao Zeng Department of Cardiology, the First Affiliated Hospital of Sun Yatsen University General characteristics (Normal Pericardial Anatomy and Physiology) is the membranous sac surrounding the heart. 2. The pericardium consists of two layers: visceral layer and parietal layer. is about 50ml pericardial fluid in the pericardial cavity. The normal functions of the pericardium ? Maintaining an optimal cardiac shape. ? Reducing friction between the beating heart and adjacent structures. ? Protecting the heart from other diseases which are caused by the neighboring ans: inflammation , TB, cancer etc. ? Preventing the overfilling of the heart. Classification of Pericardial Diseases ? Congenital defect ? Pericarditis ? acute pericarditis ? pericardial effusion ? constrictive pericaditis. ? Pericardial neoplasm ? Pericardial cysts Acute pericarditis Definition Acute pericarditis is an inflammation of the pericardium. Etiology The disease may be idiopathic or secondary to other diseases, for example ? Viral infection: coxsackievirus B, CMV ? Bacterial infection: Staphylococcus sp, Streptococcus sp, tubercle bacillus ? PostMI plications ? Drugs ? Malignancy ? Collagen vascular disease Pathology ? Early stage: ? fibrous protein pericarditis ? Progressive stage: ? Rapid effusive pericarditis → acute cardiac tamponade ? Chronic accumulation is acmodated by the expanding pericardium ? myopericarditis ? Final result: ? The exudate was pletely dissolved and absorbed ? Organization → calcification