【正文】
The Southern Medical University 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)異常與疾病 李煜生 南方醫(yī)科大學(xué) 病理生理學(xué)教研室 省部共建“重大疾病的轉(zhuǎn)錄組 與蛋白質(zhì)組學(xué)重點(diǎn)實(shí)驗(yàn)室” The Southern Medical University 基本要求 ? 掌握細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)的概念 。 ? 熟悉細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)過(guò)程的分子基礎(chǔ) 。 ? 了解細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)異常性疾病防治的病理生理基礎(chǔ)。 The Southern Medical University 第一節(jié) 信號(hào)轉(zhuǎn)導(dǎo)的基本理論 The Southern Medical University 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo) ( Cell signal transduction) ? Intercellular munication ? Intracellular signal transduction ? 細(xì)胞水平的信號(hào)傳導(dǎo)是指信號(hào)從細(xì)胞外到細(xì)胞內(nèi)的轉(zhuǎn)移。 細(xì)胞信號(hào)( Cell signal ): 引起細(xì)胞反應(yīng)的各種刺激或環(huán)境變化。 The Southern Medical University The Southern Medical University ?Specificity ?Amplification ?Transient ?Reversible ?Regulation ?Network ?Proliferation ?Differentiation ?Transformation ?Apoptosis ?Activation ?Migration ?Aging Stage I Stage II Signaling Events The Southern Medical University 1. Synthesis 2. Release 3. Transport 4. Binding 5. Signaling 6. Desensitization Signaling cell Cell signaling Target cell The Southern Medical University 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)的構(gòu)成 細(xì)胞外信號(hào)分子 細(xì)胞內(nèi)信號(hào)分子 細(xì)胞內(nèi)效應(yīng)分子 效應(yīng)調(diào)節(jié)分子 細(xì)胞外信號(hào)過(guò)程 細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo) 受體 The Southern Medical University 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)的典型過(guò)程 ? 配體與細(xì)胞膜受體的識(shí)別與結(jié)合; ? 跨膜信號(hào)傳遞; ? 細(xì)胞內(nèi)蛋白級(jí)聯(lián)的信號(hào)轉(zhuǎn)導(dǎo); ? 細(xì)胞反應(yīng); ? 信號(hào)終止。 The Southern Medical University 細(xì)胞信號(hào)的種類 ? 物理信號(hào) ?電 ?磁場(chǎng) ?光 ?聲 ?輻射 ?熱 ?力 ?滲透壓 The Southern Medical University The Southern Medical