中國醫(yī)科大學(xué)附屬一院風(fēng)濕免疫科張榕(已修改)
2024-10-15 16:41 本頁面
【正文】 中國醫(yī)科大學(xué)附屬一院風(fēng)濕免疫科 張 榕 系統(tǒng)性紅斑狼瘡 (SLE) Systemic Lupus Erythematosus 系統(tǒng)性紅斑狼瘡 Systemic Lupus Erythematosus Many Different Auto antibodies Multiple System Involvement 系統(tǒng)性紅斑狼瘡 SLE onset by sex and age 0102030405060708090Number of patients10 20 30 40 50 60 70 80A g eMa leFe ma l e系統(tǒng)性紅斑狼瘡 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 系統(tǒng)性紅斑狼瘡 Etiology geic factors environmental factors Sex hormonal factors 系統(tǒng)性紅斑狼瘡 Pathogenesis Excessive, abnormal production of “self” antibodies and formation of IC. Autoantibodies against nuclear, cytoplasmic and membrane ponents of multiple cell types in multiple ans . 系統(tǒng)性紅斑狼瘡 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 系統(tǒng)性紅斑狼瘡 Pathology 光鏡 : 特征性 :疣狀心內(nèi)膜炎 蘇木紫小體 “ 洋蔥皮樣 ” 病變 臨床應(yīng)用：皮膚狼瘡帶試驗 腎活檢 系統(tǒng)性紅斑狼瘡 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 系統(tǒng)性紅斑狼瘡 系統(tǒng)性紅斑狼瘡系統(tǒng)性紅斑狼瘡 Systemic features Fever Weak Weight loss 系統(tǒng)性紅斑狼瘡 skin and mucosa 光敏感 photosensitivity 脫發(fā) alopecia 雷諾現(xiàn)象 Raynaud’s phenomenon 口腔潰瘍 oral ulcer 皮疹 rash 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 skin and mucosa 系統(tǒng)性紅斑狼瘡 Muscle and Joint arthritis Jaccoud’s arthropathy Muscle pain、 myositis femoral head necrosis 系統(tǒng)性紅斑狼瘡 Muscle and Joint 系統(tǒng)性紅斑狼瘡 Renal lesion Proteinuria hematuria cylindruria Nephritic syndrome Renal insufficiency 系統(tǒng)性紅斑狼瘡 lupus nephritis Class I 正常 Class II 系膜增殖性 mesangial Class III 局灶增殖性 focal proliferative Class IV 彌漫增殖性 diffuse proliferative Class V 膜性
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