脂質(zhì)體運(yùn)用于胰島素口服給藥治療糖尿病的可能性外文翻譯(已修改)
2025-05-31 18:45 本頁面
【正文】 POSSIBILITY OF THE USE OF LIPOSOMES FOR ORAL ADMINISTRATION OF INSULIN IN DIABETES MELLITUS Insulin is secreted by pancreatic cells of vertebrate peptide hormones, hypoglycemic have a unique effect, so far remains the drug of choice of insulindependent diabetes. Because it is easy to gastrointestinal proteolytic enzymes degrade the oral invalid. Insulin injections are currently the most effective agents for the treatment of diabetes, usually after sc or im, its main drawback is slow to absorb the injection site, longterm injection will bring a lot of pain and inconvenience to the patient, and even inflammation, induration, allergies and other side effects. Research and easy to use, effective, safe and reliable insulin formulation is new domestic and international pharmaceutical industry issues of mon concern. Liposomes are targeted drug carriers are targeted delivery system, the same ponents with the cell membrane phospholipids, drugs are encapsulated within a phospholipid bilayer, can enhance the stability of drugs, a large number of suitable encapsulation easy to be damaged such polypeptide drug molecules, and its high patibility biofilm, can promote the absorption of drugs, the drug through the lipid bilayer slow controlled release, sustained release may play a role. Liposomes can be made into various particle sizes, by changing the position of the phospholipid liposomes that may have different surface properties, and therefore suitable for various routes of administration. Exists as a dimer of insulin molecule is a hydrophobic inner core consisting of a nonpolar side chains, the entire outer surface of the polar side chain distribution, the structural characteristics of the hydrophilic surface, a hydrophobic core. Liposome bilayer membrane, and its structure is characterized by a hydrophilic surface, the internal hydrophobic bilayer Insulin molecule having a hydrophilic surface groups, it is difficult within the liposome through a hydrophobic layer, the surface of the bilayer while the hydrophilic group to the surface of liposomes with a binding capacity, but the binding force weak,.Therefore, the bination of insulin and nonspecific liposomes, the bination of weak adsorption, resulting in a process for preparing liposome encapsulated insulin passive entrapme nt efficiency and affected to some extent (generally reported in 30% between 60%). However, because this nonspecific binding in the liposomes, the liposomes will not alter the structure of insulin, and thus will not affect the efficacy of insulin. Insulin is encapsulated within the bilayer wrapped liposomes, phospholipids and can promote the absorption of insulin from proteolytic enzymes to preserve insulin destruction and degradation of the immune system, to some extent, improved bioavailability, to ensure the efficacy, and can make the drug through the role of phospholipid bila
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