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【正文】 egulates the K+ channels through a mechanism that involves activation of MAP , this study has revealed, for the first time, an acute modulation of ion channels by findings challenge the classic view of GDNF as a longterm survival factor for midbrain dopaminergic neurons, and suggest that the normal function of GDNF is to regulate neuronal excitability, and consequently dopamine results may also have implications in the treatment of Parkinson’s to a direct petition and conflict of interest, we request that of Harvard Univ., and YY of Yale be considered as thanks for your consideration, I amSincerely yours,case2Dear Editor,We would like to submit the enclosed manuscript entitled “Ca2+binding protein frequenin mediates GDNFinduced potentiation of Ca2+ channels and transmitter release”, which we wish to be considered for publication in believe that two aspects of this manuscript will make it interesting to general readers of , we report that GDNF has a longterm regulatory effect on neurotransmitter release at the neuromuscular provides the first physiological evidence for a role of this new family of neurotrophic factors in functional synaptic , we show that the GDNF effect is mediated by enhancing the expression of the Ca2+binding protein , GDNF and frequenin facilitate synaptic transmission by enhancing Ca2+ channel activity, leading to an enhancement of Ca2+ , this study has identified, for the first time, a molecular target that mediates the longterm, synaptic action of a neurotrophic findings may also have general implications in the cell biology of neurotransmitter release.[0630][投稿寫作]某雜志給出的標(biāo)準(zhǔn)Sample Cover Letter[the example used is the IJEB]Case 3Sample Cover Letter[the example used is the IJEB]Dear Editor of the [please type in journal title or acronym]:Enclosed is a paper, entitled “Mobile Agents for Network Management.” Please accept it as a candidate for publication in the [journal title].Below are our responses to your submission and the central theme of the title: “Mobile Agents for Network Management.” This study reviews the concepts of mobile agents and distributed network management proposes a mobile agentbased implementation framework and creates a prototype system to demonstrate the superior performance of a mobile agentbased network over the conventional clientserver architecture in a large network subject/theme of the Journal the material fitsNew enabling technologies(if no matching subject/theme, enter 39。Subject highly related to [subject of journal] but not listed by [please type in journal title or acronym]) the material is important in its field and why the material should be
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