diseaseofhematopoieticandlymphoidsystem-文庫(kù)吧
2025-07-07 09:40 本頁(yè)面
【正文】 e RS cell contain two large nuclei. We term it mirror image nuclei。 Large nucleoli: the large eosinophilic nucleoli is character. ② cells closely related to RS cell The lacunar cell— shrinkage of cell cytoplasm towards cell wall and nucleus, leaving a clear space. Popcorn cell Mononuclear Hodgkin’s cell— nuclear characteristic similar to RS cell but smaller. These cell are not specifically diagnostic of Hodgkin’s disease. ③ no tumors cells lymphocyte, plasma cells, necrophilia, eosinophilic cell et al. WHO分類 分兩類 結(jié)節(jié)性淋巴細(xì)胞為主型 經(jīng)典型 The Rye classification 1. Nodular Sclerosing (40%) Thick bands of collage separating Hodgkin’s tissue: lacunar cells often numerous (often mediastinal presentation) 2. Mixed cellularity (25%) Plasma cells and eosinophils present in addition to RS cells and lymphocytes. Hodgkin disease, mixed cellularity type. 3. Lytnphocyte Depleted (15%) Very numerous RS and mononuclear Hodgkin’s cells, few lymphocytes and some diffuse fibrosis. 4. Lymphocyte predominant (5%) Very numerous lymphocytes Scanty RS cell Divited into 2 types: 1) . Nodular type 2), Diffuse type Transtion from better to worse prognosis type occurs 4→ 2→3 but nodular sclerosing usually remains true to Complications The immunity function is lower (reduce) The patient easily suffer from infection of virous and fungus. The Non Hodgkin lymphomas The non Hodgkin lymphoma are solid tumours arising in the peripheral lymphoid tissue particularly of lymphnodes but also of the extranodal sites such as the oro pharynx, the gut, skin and other sites. Grossly: The same as Hodgkin’s diseases but the mass is more soft and a few necrosis. The normal architecture of lymph node have been. Destroyed partly or entirely. Very numerous monotonous neoplastic cell flood in lymph node. The neoplastic cell may be infiltrate to the capsule of node. Classification 1. Rappaport classification The traditional classification is purely morphological criteria. The subset: ① nodular type ② diffuse type Then according to differentiated degree of tumor cell again divided into several type: (well, poorly, nodifferentiated) 2. Lukes Collins classification The NHL are classificed into T cell, B cell and null cell, histiocytic categories by using immunologist and catechetical markers as adjuncts to morphology. B細(xì)胞型淋巴瘤 小淋巴細(xì)胞 （ B） 型 漿細(xì)胞樣淋巴細(xì)胞型 濾泡中心細(xì)胞型 小核型濾泡中心細(xì)胞型 大核型濾泡中心細(xì)胞型 小無(wú)核型濾泡中心細(xì)胞型 Burkitt淋巴瘤 非 Burkitt淋巴瘤 大無(wú)核裂濾泡中心細(xì)胞型 免疫母細(xì)胞型淋巴瘤 （ B T細(xì)胞型淋巴瘤 小淋巴細(xì)胞 （ T） 型 曲折核淋巴細(xì)胞型 腦回狀核淋巴細(xì)胞型 （ 蕈樣霉菌病 ， Sezary綜合征 ） 免疫母細(xì)胞型淋巴瘤 （ T） 組織細(xì)胞型淋巴型 未定型淋巴瘤 Classification of The Non Hodgkin lymphomas 非霍奇金淋巴瘤的 KIEL分類 B細(xì)胞性 T細(xì)胞性 低度
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