【正文】 injury to cell) fatty change department of pathology 31. degeneration: are a variety of changes occurrence at intracellular or intercellular tissue normal or abnormal department of pathology 311 cellular swelling (hydropic degeneration) is the most familiar type is applied to cells when the cytoplasm bees pale and swollen due to the accumulation of fluid are called cloudy swelling department of pathology Cellular swelling department of pathology Cellular swelling department of pathology 312 fatty change accumulation of lipid droplets ( neutral fat )to intracellular many small vacuoles to form one large vacuole filling the cell and displacing the nucleus department of pathology Gross appearance: bees increasingly yellow transform into a bright yellow, soft, greasy an fatty liver( heart ) department of pathology Light microscopy: clear vacuoles within parenchymal cells fat solvents fat fusion fatty change is the most often seen the liver and heart department of pathology fatty metamorphosis (fatty change) of the liver fatty change of liver fatty heart change Hyaline refers to any alteration within cells or in extracellular space,which gives a homogeneous, glassy, pink ,any architecture appearance in routine histological sections stained with HE. department of pathology three subtypes: : important : scar tissue : kidney, plasma cells, viral infection, liver cells department of pathology three subtypes: : important : scar tissue : kidney, plasma cells, viral infection, liver cells department of pathology arteriolosclerosis arteriolosclerosis department of pathology hyaline change arteriolosclerosis three subtypes: : important : scar tissue : kidney, plasma cells, viral infection, liver cells department of pathology department of pathology 314. Amyloidosis: With light microscope, amyloid appears as an amorphous,eosinophilic,hyaline, extracellular substance accumulation Iodine solution dilute sulfuric acid Amyloid yellowred blue Congo red Amyloid pink or red amyloidosis department of pathology 315. Mucoid degeneration mucus polysaccharide accumulation in extracellular department of pathology Mucoid degeneration department of pathology 316. Pathologic pigmentation Pigments accumulated normally at intracellular or extracellular. hemosiderin lipofuscin melanin department of pathology 316. Pathologic pigmentation Pigments accumulated normally at intracellular or extracellular. hemosiderin lipofuscin melanin department of pathology HE staining Hemosiderin staining department of pathology iron stain of the liver demonstrate of hemosiderin 316. Pathologic pigmentation Pigments accumulated normally at intracellular or extracellular. hemosiderin lipofuscin melanin department of pathology Lipofuscin in myocardial cell Electro microscopy department of pathology lipochrome in the hepatocytes 316. Pathologic pigmentation Pigments accumulated normally at intracellular or extracellular. hemosiderin lipofuscin melanin department of pathology anthracotic pigment in macrophages in a lymph node department of pathology Melanin body 317. Pathologic calcification Calcium salts are normally found only in bone and teeth. In disease states, however, tissue can bee hardened by deposits of calcium salts,this process is called calcification. Calcification may be: dystrophic: abnormal tissue metastatic: normal tissue Calcium salts Dystrophic calcification ?Atheromatous plaque ?Old tuberculous lesions ?Fat necrosis ?Breast lesions department of pat