【醫(yī)學(xué)課件】代謝綜合征ppt課件-文庫吧
2024-12-31 20:53 本頁面
【正文】 etes Mellitus and Its Complications: Report of a WHO Consultation. Geneva: WHO, 1999. | Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA 2021。285:24862497. Therapeutic Implications: According to Underlying Causes ? Insulin resistance ? Treat insulin resistance ? Lifestyle: especially obesity ? Prevent and treat obesity ? Subclinical inflammation ? Treat obesity ? Statins, TZDs, etc. Risk Factor Defining Level Abdominal obesity (Waist circumference) Men Women 102 cm (40 in) 88 cm (35 in) TG ?150 mg/dl HDLC Men Women 40 mg/dl 50 mg/dl Blood pressure ?130/?85 mm Hg Fasting glucose ?110 mg/dl ATP III: The Metabolic Syndrome Diagnosis is established when ?3 of these risk factors are present Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. JAMA 2021。285:24862497. 40–49 Prevalence of the NCEP Metabolic Syndrome: NHANES III by Age Ford ES et al. JAMA 2021。287:356359. Prevalence, % 20–70+ Age, years 20–29 30–39 50–59 60–69 ?70 Men Women 24% 23% 8% 6% 44% 44% 0%10%20%30%40%50%0%10%20%30%40%Prevalence of the NCEP Metabolic Syndrome: NHANES III by Sex and Race/Ethnicity Prevalence, % Men Ford ES et al. JAMA 2021。287:356359. Women White African American Mexican American Other 25% 16% 28% 21% 23% 26% 36% 20% Prevalence of CHD by the Metabolic Syndrome and Diabetes in the NHANES Population Age 50+ CHD Prevalence % of Population = No MS/No DM % MS/No DM % DM/No MS % DM/MS % % % % % 0%5%10%15%20%25%Alexander CM et al. Diabetes 2021。52:12101214.. ATP III Metabolic Syndrome: Therapeutic Implications ? Focus on obesity (especially abdominal obesity) as the underlying cause of the metabolic syndrome ? Therefore, prevent development of obesity in the general population ? Also, treat obesity in the clinical setting (NHLBI/NIDDK Obesity Education Initiative) Variable Odds Ratio Lower 95% Limit Upper 95% Limit Waist circumference Triglycerides HDL cholesterol* Blood pressure* Impaired fasting glucose Diabetes* Metabolic syndrome Different Components of the NCEP Metabolic Syndrome Predict CHD: NHANES *Significant predictors of prevalent CHD Prediction of CHD Prevalence using Multivariate Logistic Regression Copyright 169。 2021 American Diabetes Association From Diabetes, Vol. 52, 2021。 12101214 Reprinted with permission from The American Diabetes Association. 0% 2% 4% 6% 8% 10%BMI per kg/m2 HDLC per mg/dl decrease SBP per mm Hg FPG per mg/dl Different Components of the NCEP Metabolic Syndrome Predict Diabetes: San Antonio Heart Study Stern MP et al. Ann Intern Med 2021。136:575581. Risk of Type 2 Diabetes per Unit Change in Risk Trait Levels 8% 2% 4% 7% WHO. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation. Geneva: WHO, 1999. WHO Metabolic Syndrom
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號-1