生物技術(shù)藥物,12stem cell-文庫(kù)吧
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【正文】 is ( 5%) ? Injected transgene integrates at random sites within the host genome ? Variable levels of expression ? Genes for selection not required Efficiency of Microinjection Mouse Transgenesis Embryonic Stem Cell Method Mouse Transgenesis Embryonic Stem Cell Method ? Efficient transfection in culture ? Positivenegative selection and enrichment of ES cells in culture ? Targeted insertion in host cell genome ? Targeted gene disruption and development of geneknockout strains Negative Selection Positive Selection Gene Knockout Transgenic Mice: Applications ? Model systems for human diseases and feasibility studies for production of therapeutic agents ? Mouse models for human diseases such as Alzheimer disease, arthritis, muscular dystrophy, tumorigenesis, hypertension, neurodegenerative disorders, and coronary disease Animal Cloning: To Clone, or not to Clone Dolly Geia Agriculture Education Curriculum Office July 2022 Pros: ? Cure human diseases ? Using animal ans ? Create animals that are disease resistant ? More consistent food products ? Save endangered species Cons: ? Public perception ? Use technology to clone humans ? Expensive ? Not efficient ? Cloned products can?t be marketed Cloning Definition: The process of making identical genomic copies of an original animal. Encyclopedia Britannica: An individual anism that was grown from a single body cell of its parent and that is geically identical to it. Brief History of Cloning ? 1902: Walter Sutton proves chromosomes hold geic information. ? 1902: German scientist Hans Spemann divides a salamander embryo. ? Spemann proposes a “fantastical experiment” Brief History of Cloning ? 1952: Briggs and King clone tadpoles. ? 1953: Watson and Crick find the structure of DNA. ? 1962: John Gurdon clones frogs from differentiated cells. ? 1963: . Haldane coins the term ?clone?. Brief History of Cloning ? 1977: Karl Illmensee creates mice with only one parent, ? 1984: Twinning create geic copies from embryonic cells. ? 1996: First animal cloned from adult cells is born. The Cloning Process ? 1978: Splitting embryos ? 1986: Embryo Cloning
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