【正文】
拮抗性、網(wǎng)絡(luò)性 細胞因子的分類 ?白細胞介素 Interleukin (IL) ?干擾素 Interferon (IFN) ?腫瘤壞死因子 Tumor necrosis factor (TNF) ?集落刺激因子 Colony stimulating factor (CSF) ?生長因子 Growth factor ?趨化性細胞因子 Chemokine 白細胞介素 Interleukin (IL) ? Interleukins are secreted by some leukocytes and act upon other leukocytes. ? Interleukins 1–33 have been identified IL2 ?Produced by CD4 T cells ?T cell growth factor IL 4 Produced by Th2 /mast cells/basophils IL12 集落刺激因子 Colony stimulating factor ?Stimulate the formation of cell colonies in bone marrow cultures ?Supporting the growth and directing the differentiation of hematopoietic cells 各種集落刺激因子的特性 ? 具有干擾病毒感染和復(fù)制的能力。分為IFNα, β, γ ? Ⅰ 型干擾素: IFNα和IFNβ,由 DC和病毒感染細胞產(chǎn)生,主要功能:抗病毒 ? Ⅱ 型干擾素: IFNγ,由活化 T細胞和 NK細胞產(chǎn)生,主要功能:免疫調(diào)節(jié) 干擾素 (IFN) IFN γ IFNγ is produced by T cells and NK cells ? 分泌型 ?TNFα 單核細胞產(chǎn)生,使腫瘤出血壞死,誘導(dǎo)細胞凋亡,產(chǎn)生惡液質(zhì) ?TNFβ 活化的 T細胞產(chǎn)生 ? 膜型 TNF: LTβ ? 功能:殺傷腫瘤,免疫調(diào)節(jié),發(fā)熱和炎癥 腫瘤壞死因子 (TNF) 趨化