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nt UTI’s ? Atopic diseases ? Immune system enhancement ? H pylori infections ? Dental caries ? Radiation induced diarrhea ? Cardiovascular risk reduction ? Constipation ? Rheumatoid arthritis Probiotics: Proposed uses Rating the Evidence Floch et al (2022) Natural Standard (2022) Infectious diarrhea A B Antibioticassociated diarrhea A C Diarrhea prevention B B IBS C B Atopic dermatitis/Allergy B? B/C Ratings: A: strong B: good C: fair Floch, et al. Remendations for Probiotic Use. J Clin Gastro. 40(3). 2022 Probiotics: Proposed uses Rating the Evidence Floch et al (2022) Natural Standard (2022) Ulcerative colitis C B Crohn’s disease C H pylori infection C A NEC C Bacterial vaginosis C C UTI’s C Ratings: A: strong B: good C: fair Floch, et al. Remendations for Probiotic Use. J Clin Gastro. 40(3). 2022 Probiotics: the evidence ? Antibioticassociated diarrhea: – D’Souza et al (BMJ 2022) ? Systematic review of 9 placebocontrolled studies (2 in children) ? Various probiotics (4 uses S Bouladarii) ? 60% reduction in antibiotic associated diarrhea pared with placebo (OR , 95% CI )