【正文】
opean Respiratory Society proposed a new classification for lung adenocarcinomas. ? In the new classification system, the term bronchioloalveolar carcinoma (BAC) is no longer used. The former BAC concept applicable to multiple categories in the new classification system, such as AIS, MIA and the mucinous subtype of adenocarcinoma. Both AIS and AAH lesions are classified as preinvasive adenocarcinoma under the new classification system ? 第二十七頁(yè),共四十頁(yè)。 ? Early stage lung cancers often present as GGNs in CT images。 thus, it is important to be familiar with the characteristics of GGNs with malignant potential, as timely surgical resection will improve patient survival and quality of life, and for patients with benign GGNs, unnecessary surgical procedures can be avoided. 第二十八頁(yè),共四十頁(yè)。 ? Clinical data have shown that nodule size is an independent predictive factor of malignancy, with size increasing the likelihood of malignancy increasing , consistent with our results that the mean sizes of GGNs in benign, preinvasive and adenocarcinoma groups were mm, mm and mm. ? Clinical experience has demonstrated that some mon imaging features of malignant nodules, such as pleural indentation, spiculation and lobulation, are seldom seen in very early stage malignant GGNs. 第二十九頁(yè),共四十頁(yè)。 ? This demands further investigation of this particular abnormal imaging finding to minimise misdiagnosis. In the management of GGNs in our patients, clinical guidelines from the Fleischner Society and National Comprehensive Cancer Network (NCCN) were referenced . ? Each individual case was discussed by a multidisciplinary team, including diagnostic radiologists, thoracic surgeons and pathologists, to generate consequent management strategies. ? All patients received adequate followup observation with/without supportive or antiinflammatory treatment, which explained the fact that four GGNs disappeared prior to the next scheduled CT examination. 第三十頁(yè),共四十頁(yè)。 ? Except for these four cases without biopsy, nodular lesions in the remaining 104 patients were surgically removed because of the continuous increase in size and/or mass on followup imaging studies. ? Considering the dramatically increasing incidence of lung cancer in China, patients and physicians are very alert to it and the treatment might be more aggressive than in Western countries. 第三十一頁(yè),共四十頁(yè)。 ? Tumour biology studies have revealed that vasculature remodelling or neoangiogenesis is one of the initiating events occurring in the early stage of tumour development. Therefore, analysis of GGNs and related blood supplying vessels could provide information on GGN differentiation. ? Small blood vessels and the relationships between vessels and lesions can be readily revealed and evaluated in CT images acquired with modern multidetector scanners, especially when imaging data are postprocessed using advanced puter techniques, including MPR and CPR. ? Many studies have demonstrated that relationships between SPNs and vessels, especially the vascular convergence sign (VCS), are valuable for estimation of the malignancy potential of SPNs 第三十二頁(yè),共四十頁(yè)。 ? Some studies indicated that disease progression from AAH, AIS, MIA to IAC is a plicated, polygeneinvolved dynamic process. MIA or IAC may gradually develop from AAH and AIS . Interstitial fib