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nd noradrenaline have a similar molecular structure and share the same uptake and storage mechanisms in the sympathetic nerve endings. ? MIBG is not metabolized by monoamine oxidase。 thus, localization of MIBG relates to the presence of sympathetic nerves and to tissue noradrenaline content. ? MIBG is currently labelled with 123I for diagnostic purposes and with 131I for therapy 28/11/2020 EF=13% EDV=350 ml 10/07/2020 EF=60% EDV=110 ml Eur J Nucl Med molecular Imaging, 2020。 36: 2068 I123mIBG myocardial imaging for assessment of risk for a major cardiac event in HF Pts Agostini D. Eur J Nucl Med Mol Imaging (2020) 35:535–546 Jacobson AF, et al. J Am Coll Cardiol. 2020 May 18。55(20):221221 2Year Cardiac Death and AllCause Mortality Rates Jacobson AF, et al. J Am Coll Cardiol. 2020 May 18。55(20):221221 Cumulative Event Curves in Relation to BNP, LVEF, and H/M Jacobson AF, et al. J Am Coll Cardiol. 2020 May 18。55(20):221221 Cumulative Event Curves in Relation to BNP, LVEF, and H/M Jacobson AF, et al. J Am Coll Cardio