diseaseofhematopoieticandlymphoidsystem-閱讀頁
2024-08-10 09:40本頁面
【正文】 onic 2. According to the Leukemic cell type Myelocytic Lymphocytic 4 types: AML (59%), ALL (%), CML (%), CLL (%) shanhai Acute leukemia(AML) Acute myelogenous leukemia(AML) Classfication: M0,minimally differentiated AML（最少分化） M1, AML without differentiation（未分化） M2 AML with differentiation（成熟型） M3 acut promyelocytic leukemia（早幼粒細(xì)胞） M4acut myelomonocytic leukemia（粒單核細(xì)胞） M5acut monocytic leukemia（單核細(xì)胞） M6acut erythroleukemia（紅白血?。? M7Acute megakaryocytic leukemia(巨核細(xì)胞） C. Pathologic feature of acute leukemia 1. Peripheral blood: WBC 2022050000/μl Myeloblastic Lymphoblastic 3090% 2. Bone marrow: Normal marrow is diffuse replaced by leukemic cells. Bone marrow develop a muddy, red brown to greywhite color. In AML, bone is infiltrated by tumor cell form tumorous mass, termed chloroma. 3. Lymph node Enlargement, normal structure of LN is destroyed partly or entirely. 4. Liver Enlargement middle degree. In ALL, Leukemic cell Infiltrates the portal areas, but in AML, Leukemic cell are present within the sinusoids throughout the lobule. 5. Spleen Only moderate spleenmegaly, 5001000gm. In AML Leukemic cells infiltrate to the red pulp and venous sinuses. In ALL, the white pulp is primarily involved. Ultimately the speen structure is obliterated. D. Pathologic feature of chronic Leukemia 1. Peripheral Blood: WBC 100000800000 /μl The most cells are more mature forms. 2. Bone Marrow BM proliferate actively, in CML the most of tumor cells are myelocyte and metamyelocyte. In CLL, the most of tumor cells are mature lymphocyte. 3. Spleen Massive splenmegaly is character of CML 5000gm or more In CLL, between 5001000gm In CML, numerous areas of pale infarction Leukemic cell infiltrate focal or diffuse, Ultimately the spleen structure is obliterated. 4. Liver It’s same as acute Leukemia E. Result and Complication Progrosis is very poor. Survival period: Acute Leukemia 36 mo. Chronic Leukemia 5 years But all of patients would be died Cause of die: 1. Infection 2. Hemorrhage 3. Organ function failure C. Result 5 year survival rate: Low grade malignant 100% Middle grade malignant 28% High grade malignant 0 Section 5 Malignant Histiocytosis (M H) A. Definition: M H is an aggressive and rapidly fatal systemic malignant tumor of the mononuclear phagocyte. 組織細(xì)胞增生癥 是各種組織細(xì)胞或巨噬細(xì)胞增生性疾病的總稱 惡性 組織細(xì)胞淋巴瘤 . 之間 ?朗格漢斯組織細(xì)胞增生癥 良性 淋巴結(jié)反應(yīng)性組織細(xì)胞增生 急性彌漫性朗格漢斯細(xì)胞組織細(xì)胞增生癥 acute sisseminated Langerhans cell histocytosis 朗格漢斯細(xì)胞又叫樹突狀抗原提成細(xì)胞，可分布與多個(gè)器官最常見與皮膚， 多見與 2歲一下兒童。－－－肺－－骨質(zhì)破壞 貧血，反復(fù)感染，不治療迅速死亡。 嗜酸性肉芽腫 eosinophilic granuloma 特征為 朗格漢斯細(xì)胞在骨髓腔中聚集 單發(fā)，多發(fā)， 骨質(zhì)破壞 常見與顱骨，肋骨和股骨，有骨痛，病理
化學(xué)相關(guān)推薦
鄂ICP備17016276號-1