篇第九章白血病ppt課件-閱讀頁(yè)
2025-01-20 15:39本頁(yè)面
【正文】 stgrowing and can overrun the body within a few weeks or months. By Contrast, chronic leukemia is slowgrowing and progressively worsen over years Acute versus chronic leukemia Acute: the blood cells of acute leukemia remain in an immature state, so they reproduce and accumulate very rapidly. Therefore, they need treatment immediately, otherwise the disease may be fatal within few months Chronic: in Chronic leukemia, the blood cells eventually mature, or partially mature. But they are not “normal”. They remain in the blood much longer than normal blood cells and they can not act functional cells well Myelogenous versus lymphocytic leukemia If the leukemic cells arise from myeloid pluripotential stem cells: myeloid leukemia If the leukemic cells arise from lymphocytic pluripotential stem cells: lymphocytic leukemia Clinical manifestations Leukemic hematopoiesis Normal hematopoiesis marrow failure Infiltration Marrow failure Anemia (loss of erythocytes): fatigues, pallor weakness, reduced exercise tolerance Fever and infection (Poor infection fighters) Abnormal bleeding (loss of platelets) Infiltrations Oral tissue: swollen painful, and bleeding gums Splenomegaly and hepatomegaly Lymph node enlargement Bone or joint pain CNSheadaches, seizures, weakness, blurred vision and vomiting Blood test findings Anemia is a constant red cells or immature red blood cell may be present. Thrombocytopenia is nearly always present at the time of total leukocyte counts can be high, normal or low. Immature hematopoietic cells are almost present in the blood Marrow findings Normal bone marrow AML marrow Cytogeic findings Diagnosis a
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