北大生化ppt課件-在線瀏覽
2025-06-23 12:18本頁面
【正文】 iming isomerization cleavage The second stage of the glycolytic pathway: The payoff phase Only ~5% of the potential energy of the glucose molecule is released during glycolysis. All the enzymes catalyzing glycolysis have been found in the cytosol. The production of ATP per glucose in glycolysis is 42=2. The pathways of carbons, phosphoryl groups, and electrons for glycolysis: Glycolytic enzymes may form multienzyme plexes within cells ? When proteins are purified from extracts of broken cells in diluted solutions, noncovalent interactions between proteins could be destroyed (., higher level anization destroyed). ? Kiic and physical evidences suggest that the enzymes act to catalyze the ten reactions of glycolysis pathway (as enzymes act in other metabolic pathways) may assemble into multienzyme plexes, where intermediates are directly channeled from one enzyme to another, without entering the aqueous solutions, a phenomenon called “substrate channeling”. The glycolytic enzymes very likely form multienzyme plexes. Substrate channeling Dilution dissociation Fermentation: pyruvate is converted to lactic acid or ethanol under anaerobic conditions Pyruvate is reduced to lactate, leading to NAD+ regeneration when O2 lacks (thus allowing glycolysis to continue)。 substrate channeling。Chapter 14 Glycolysis and the Pentose Phosphate Pathway Glycolytic pathway。 Fermentation。 Pentose phosphate pathway. To be lectured by Professor Zengyi Chang on September 19, 2022 The chemistry of glucose catabolism was elucidated over about 100 years ? The anaerobic breakdown (fermentation) of glucose to ethanol and CO2 by yeast has been exploited for many centuries in baking and winemaking. ? Scientific investigation of the chemistry of glucose breakdown began in the mid19th century. ?
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