世界范圍內(nèi)的麻疹疫苗株及其應(yīng)用-展示頁
2025-08-10 17:29本頁面
【正文】 毒疫苗研究室 DEFINITION Measles vaccine (live) is a freezedried preparation of a suitable attenuated strain of measles virus. The vaccine is reconstituted immediately before use, as stated on the label, to give a clear liquid that may be coloured owing to the presence of a pH indicator. SEED LOT The strain of measles virus used shall be identified by historical records that include information on the origin of the strain and its subsequent manipulation. To avoid the unnecessary use of monkeys in the test for neurovirulence, virus seed lots are prepared in large quantities and stored at temperatures below ?20 176。 ?1964年，衛(wèi)生部上海、長春、北京生物制品研究 所分別篩選出減毒麻疹病毒株滬 19長 47和京 55， 1965年同時通過國家檢定 ，成為我國正式的 疫苗株。 ?1960年冬張箐從上海典型麻疹患兒血液標(biāo)本分 離 1株“滬 191”。 M. Bernice Leagus, PhD 前蘇聯(lián)研制的列寧格勒 16株 成都生物制品研究所 病毒疫苗研究室 An effective live measles vaccine was developed in 19591962 by A. A. Smorodintsev and his colleagues at the Leningrad Pasteur Institute from the original strain of Leningrad16 (L16) measles virus. This strain was isolated from a patient with measles in a monolayer of epithelial kidney cells from newborn guinea pigs. After 16 passages, a highly immunogenic strain with low reactogenicity was produced。 Joseph Stokes, Jr., MD, DSc。 Eugene B. Buynak, PhD。 Pfizer 19631975 MeaslesL Generic Lilly, Parke Davis, Philips Roxane 19631975 Live, more attenuated Schwarz (derived from Edmonston A) Lirugen Pitman MooreDow 19651976 Moreattenuated Enders (derived from Edmonston B) Attenuvax Merck Sharp amp。 世界范圍內(nèi)的麻疹疫苗株及其應(yīng)用 麻疹病毒的分類 成都生物制品研究所 病毒疫苗研究室 ?Measles virus (MV) is an enveloped nonsegmented negative strand RNA virus of the family Paramyxoviridae, genus
環(huán)評公示相關(guān)推薦
鄂ICP備17016276號-1