出血熱病毒-醫(yī)學微生物學課件-文庫吧資料
2025-01-01 03:32本頁面
【正文】 Microbiology, Harbin Medical University 根據(jù)抗原和基因結構分型（ 10型） ? Hantaan（漢灘型） ? Seoul type（漢城型） ? Puumala type ? Sin Nombre（辛諾柏型） Department of Microbiology, Harbin Medical University 流行病毒學 Epidemiology ? Natural host: Rodent Apodemus agrarius (Stripped field mice, 黑線姬鼠 ) ? 傳染源：黑線姬鼠、褐家鼠、大林姬鼠 ? Viral contamination es from rodent urine, stool, salivary secretion ? Seasonal and regional distribution (autumn and winter, .) ? The infection route is still uncertain. The possible entries are respiratory tract, mouth, and direct contact Rodent Carriers of Hantaviruses Stripped field mouse (Apodemus agrarius) Bank vole (Clethrionomys glareolus) Deer Mouse (Peromyscus maniculatus) Rat (Rattus) Department of Microbiology, Harbin Medical University 臨床特點 Clinical Features ? Incubation: 2 weeks, HFRS ? Pathogenesis mechanism is unknown. Immunological reaction may play role ? 極低的隱性感染率 Very low subclinical infection rate (14%) ? 病后穩(wěn)定的免疫力，一般不再發(fā)病 Stable humoral immunity. no repeat infection Department of Microbiology, Harbin Medical University 致病性 Pathogenesis ? The multisystem pathology of HVD is characterized by damage to capillaries and small vessel walls, resulting in vasodilation and congestion with hemorrhages ? Classically, hantavirus disease consists of 5 distinct phases. These phases may be blurred in moder
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