章b淋巴細(xì)胞的活化與抗體產(chǎn)生-文庫吧資料
2025-05-06 04:27本頁面
【正文】 感染中具有重要意義 HEV 1. Antigen loaded dendritic cells migrate from subcapsular sinus to paracortical area of the lymph node DC B B B B B B T T T T 2. T cells migrate through HEV and are trapped by antigen on DC B 4. B cells migrate through HEV most pass through the paracortex and primary follicle. T T T T 3. T cells proliferate Some interact with T cells and proliferate to form a primary focus B cells (90%) and T cells (10%) migrate to form a primary follicle B B B B B B T Primary follicle formation 第四節(jié) T、 B細(xì)胞活化信號的轉(zhuǎn)導(dǎo) 一、 T細(xì)胞活化信號轉(zhuǎn)導(dǎo) ? 激酶：使底物中磷酸化 – PTK – PK ? 磷酸酶：使底物中磷酸化氨基酸去磷酸 – CD45 ? 第一信號的轉(zhuǎn)導(dǎo) – CD3分子 ITAM磷酸化 – ZAP70磷酸化 – IP3， DAG途徑 – Ras/Rac途徑 ? 第一信號的轉(zhuǎn)導(dǎo) CD45 Lck， Fyn活化 CD3分子 ITAM磷酸化 ZAP70募集并磷酸化 PLCγ 磷酸化 Ras活化 IP3途徑 DAG途徑 MAPK途徑 NFAT NFκ B AP1 基 因 轉(zhuǎn) 錄 Lck Fyn Zap70 Receptor associated kinases accumulate under the membrane in close proximity to the cytoplasmic domains of the TcR CD3 plex CD4 MHC II MHC II CD45 TCR binds MHCpeptide antigen phosphatase CD45 activates kinases such as Fyn P Early T cell activation The tyrosine kinase ZAP70 binds to the phosphorylated ITAMs of CD3z further activation requires ligation of the coreceptor, CD4 Zap70 Fyn phosphorylates the ITAMs of CD3g, d, e and z ITAMS Lck Fyn CD4 CD45 P MHC II T cell activation Lck Fyn P MHC II Zap70 T cell activation Binding of CD4 coreceptor to MHC class II brings Lck into th
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