ropofol(diprivan)andit39sadverseeffectinanesthesia：丙泊酚異丙酚和它的不良影響在麻醉-文庫吧資料
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【正文】 m decreases the dose and time required to achieve hypnosis with propofol induction without delaying emergence from anesthesia. ? Additional administration of flumazenil further shortens the time to emerge from midazolampropofol anesthesia. Seizurelike phenomena and propofol: a systematic review. Neurology Volume 58 ? Number 9 ? May 14, 2022 Copyright 169。 pruritus [Peds: 2%]. Events without an * or % had an incidence of 13%. * Incidence of events 310%. Adverse Effects ? postoperative unconsciousness ? Transient local pain: larger veins。 tachycardia nodal [Peds: %]。Propofol (Diprivan) and It’s Adverse Effect in Anesthesia Liu, ChihMin 2022819 2,6diisopropylphenol Propofol ? Indications: Anesthesia, general ? Pregnancy Category B ? FDA Approved 1989 Oct ? 2,6diisopropylphenol ? molecular weight of . ? isotonic ? pH of Mechanism of Action ? The actual mechanism of action is unknown, but it is postulated that propofol mediates activity of the GABA receptors. ? rapid sedation with minimal excitatory activity ? no analgesic properties Pharmacokiics ? eliminated by hepatic conjugation to inactive metabolites, excreted by the kidney ? No dosage adjustments are needed for patients with renal or hepatic failure ? Geriatrics ? agerelated decrease in volume of distribution ? higher peak plasma concentrations ? cardiorespiratory effects including hypotension, apnea, airway obstruction, and/or oxygen desaturation INDICATIONS AND USAGE: ? induction and/or maintenance of anesthesia ? in adult patients and pediatric patients greater than 3 years of age ? not remended for obstetrics ? not remended for use in nursing mothers Pediatric Use ? not remended in: ?induction of
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