創(chuàng)新實(shí)驗(yàn)答辯王超ppt課件(參考版)
2025-01-17 09:18本頁(yè)面
【正文】 謝謝大家出席今天的答辯 . The End! Thank You! 。 謝謝王冠海、李本剛、蔡祥、馬棟、孔韜等師兄，張 碧芳和李潔梅、朱仙娥等師姐在實(shí)驗(yàn)中給予的指導(dǎo)和幫 助。 致 謝 本論文是在張黎明老師的悉心指導(dǎo)和親切關(guān)懷下完成 的，深深感謝張老師的諄諄教誨。 載藥膠束的累積釋放率與時(shí)間、溫度、 pH值有關(guān)；且接枝率越低、 pH值越高、溫度越高，藥物釋放速度越快且達(dá)到平衡時(shí)的累積釋放率越 高。 衍生物膠束的粒徑在 ，且隨接枝率的增加， 膠束的粒徑逐漸增大；相同接枝率的衍生物膠束隨溶液 pH值的增大，粒 徑也增大。 0 500 1000 1500 2022 250050510152025303540455055 C H I P L A3 C H I P L A2 C H I P L A1Accumulated release (%)T (m i n )Fig. 17 First order kiics model fit of indomethacin release form CHIPLA nanoparticles with different grafting content in PBS(pH= T=25℃ ) Samples 一級(jí)模型 Weibull模型 Higuchi模型 R2 Q∞ M K1 R2 b k R2 KH CHIPLA1 CHIPLA2 CHIPLA3 Table 6 the results of indomethacin release form CHIPLA nanoparticles with different grafting content fitted with 3 different models 0 500 1000 1500 2022 2500 3000 3500100102030405060PH =PH = PH =C H IP L A2 PH =6 .1 PH =7 .4 PH =8 .0Accumulated release (%)T ( m i n )Fig. 18 First order kiics model fit of indomethacin release form CHIPLA nanoparticles with different pH (fabrication temperature: 25℃ ) pH 一級(jí)模型 Weibull模型 Higuchi模型 R2 Q∞ M K1 R2 b k R2 KH Table 7 the results of indomethacin release form CHIPLA nanoparticles in different pH value fitted with 3 different models 0 500 1000 1500 2022 25001 00102030405060C HI P L A2 T =2 5oC T =3 7oC T =4 7oCAccumulated release (%)T (m in )Fig. 19 First order kiics model fit of indomethacin release form CHIPLA nanoparticles in different temperature in PBS= T/℃ 一級(jí)模型 Weibull模型 Higuchi模型 R2 Q∞ M K1 R2 b k R2 KH 25 37 47 Table 8 the results of indomethacin release form CHIPLA nanoparticles in different temperature fitted with 3 different models 結(jié)
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