20xx年醫(yī)學專題—antianginal-drugs(抗心絞痛藥)-wenkub.com
2025-10-21 14:05 本頁面
【正文】 Ca2+ antagonists,第三十一頁，共三十一頁。Postinfarction angina (梗死(ɡěnɡ sǐ)后心絞痛)。 Ca2+ antagonists,第三十頁，共三十一頁。 Typical drugs and their properties Antihypertensive drugs Classification。,Sammary,Cardiovascular pharmacology,第二十七頁，共三十一頁。 ?: decrease, ? ?: markedly decrease。,B. Clinical uses stable and variant type: nifedipine, verapamil, diltiazem unstable type: verapamil, diltiazem,2. Antianginal drugs,Actions of DHP (like nifedipine) are similar to those of nitroglycerin Actions of verapamil and diltiazem are similar to those of ? blockers,第二十三頁，共三十一頁。 but not used for variant angina pectoris C. Notes Dose individualization: starting from small dose Withdraw gradually and slowly: symptom rebound Combination with nitroglycerin,2. Antianginal drugs,第十九頁，共三十一頁。,2.1 Other nitrates Isosorbide dinitrate (硝酸(xiāo suān)異山梨酯) Isosorbide5mononirate (5硝酸異山梨酯) Compared with nitroglycerin: Similar but weaker effect Acting slowly but lasting longer Larger individual variation and more adverse effects,2. Antianginal drugs,第十六頁，共三十一頁。ng d224。,Mechanism of the effect of nitroglycerin and other nitrates,2. Antianginal drugs,第十三頁，共三十一頁。,Effects of antianginal drugs: Reducing oxygen demands Reducing heart rate and contractility Dilating systemic arteries and veins ( ? wall tension by lowering heart loads) Increasing oxygen supply Dilating conduct coronary arteries ( ? coronary blood flow) Promoting regional distribution ( ? in ischemic regions) Others: Anti platelet coagulation and thrombus formation,1. OVERVIEW
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