【正文】 蛋白提取液(40 mg), 細(xì)胞上清液(20 ml)。hMET ex 20 Rw: 50GGGCTCCTCTTGTCATCAGC3。EBC1 and GTL16 細(xì)胞對(duì)MET TKIs PHA665752(EBC1 RPHA 50 nM and GTL16 RPHA 150 nM)都有耐受性，并且向描述的那樣培養(yǎng)可以一直保持PHA665752的存在。D 提供的通過暴露親代細(xì)胞方法來增加抗MET單價(jià)單克隆抗體的濃度。 EBC1 細(xì)胞從一個(gè)患有轉(zhuǎn)移皮膚腫瘤的病人取得，這個(gè)患者還患有肺鱗狀細(xì)胞癌，病例是從日本癌癥資料庫購(gòu)買得到。在這個(gè)研究中我們表明了不斷用MVDN30來治療沉癮癌細(xì)胞會(huì)使其具有抗性的原因是MET基因的大量復(fù)制和MET的過度表達(dá)超過了MVDN30對(duì)其有效下調(diào)并使其失去活性的的能力。它的誘導(dǎo)、再結(jié)合、達(dá)到MET脫落閾值的能力使其有抑制活性，剩余的跨膜片段通過蛋白酶體降解途徑處理掉。在活體和動(dòng)物模型進(jìn)行的研究已經(jīng)表明用TKIs長(zhǎng)期治療會(huì)導(dǎo)致機(jī)體的治療耐受性。在腫瘤組織中，浸潤(rùn)性生長(zhǎng)的增進(jìn)可以迫使腫瘤細(xì)胞從腫瘤組織中分解下來侵蝕基底膜，滲入基質(zhì)中，甚至定居于新的組織中來實(shí)現(xiàn)轉(zhuǎn)移。在癌癥治療中的可以抗癌的RTKs單克隆抗體已經(jīng)被批準(zhǔn)在乳腺癌和結(jié)腸癌中使用(分別針對(duì)HER2和表皮生長(zhǎng)因子受體)并可作為抗血管增生的藥物（針對(duì)血管內(nèi)皮生長(zhǎng)因子受體）。酪氨酸激酶抑制劑是一種可以抑制靶蛋白酶活性的小分子物質(zhì)。癌基因和人類癌癥密切相關(guān)，酪氨酸激酶起著決定性作用。這就意味著單個(gè)基因的抑制或死亡是由于它們的沉癮，或者至少抑制它們的生長(zhǎng)（溫斯坦,2002）。結(jié)果表明一種不連續(xù)的通過抗體和化學(xué)激酶抑制劑聯(lián)合治療可能會(huì)使靶向治療的臨床反應(yīng)和對(duì)MET抗體治療旁路的抗性增加。這種過度表達(dá)可以使單克隆抗體的“脫落”活動(dòng)達(dá)到飽和，并且能夠防止表面的MET受體的有效的下調(diào)和抑制劑的活化作用。s features, nice screen test for embedded smart devices, testers, test device, the plexity of the network environment and increase the efficiency of automated :《 Journal of Electronic Science and Technology》第四篇：專業(yè)英語論文翻譯MET基因復(fù)制數(shù)量的增加賦予單克隆抵抗體抗MET的能力并且建立藥物依賴性關(guān)鍵詞：MET，MVNV30單克隆抗體，酪氨酸激酶抑制劑，抗性，藥物依賴性 【摘要】：被MEI原癌基因編碼的酪氨酸激酶受體領(lǐng)導(dǎo)了具體抑制劑的發(fā)展并在癌癥中起很重要的作用，其中現(xiàn)在一些正處于前進(jìn)的臨床試驗(yàn)階段就以前的經(jīng)驗(yàn)表明對(duì)大多數(shù)靶向治療最主要的限制是抗性的出現(xiàn)。s RF performance, usually the base station simulator to provide a device in which the wireless network environment, and use programming interface, the software environment to control the device, making the plex network environment, the target device under test as System EvaluationIn order to evaluate the effectiveness of the system, we designed a parative testing laboratory in the Ministry of Information Industry of the test project for will test engineers divided into two groups, the first group to use this system MobileTest test, the second group uses the industry39。來源于：《 Journal of Electronic Science and Technology》專業(yè)英語期末考查第7頁附：英文原文Embedded system research 1 IntroductionIntelligent Software Agent is the ability to perform specific tasks for the user, with a certain degree of intelligence, able to perform some tasks and autonomy in a proper manner and environment interactions software has autonomy, responsiveness, learning and social and other makes it suitable for highly dynamic environment to make a timely technology and the development of new generation mobile munication networks makes the emergence of a large number of embedded intelligent of these devices with embedded operating system support, and run an increasingly rich to test for these applications to be a need to article Intelligent Agent technology into embedded devices test, using the target device Agent, test control Agent, Network Agent and treatment were simulated test equipment, test engineers and test plexity of the environment, the use of Agent has its own characteristics, proposed An effective automated Related research and ideas of this articleAgent possess autonomy, responsiveness, learning and social and other features, makes it very suitable for handling plex problems in the test technology in the test area will already have some relevant research, the following is a specific Choi and Byoungju Choi [1] proposed a testing tool based on Agent technology, which through the use of Agent to handle user interface and test those interactions, the use of Agent to carry out the test case test case selection choices, and use the Agent for regression testing regression testing, so a good automated software they can only be made in a large number of test selection techniques select test cases has been the best use cases, write test cases can not reduce its 第8頁Other studies will Agent technology applied to a field Qi, David Hung and Eric Wong [3] proposed a Webbased Agent technology application testing technology to reduce their use of the network application testing method not only for Web application testing, but also for the testing of embedded intelligent the actual testing process, testers great task is still the preparation of various test cases, to really improve test efficiency, we must improve the general test scripts, reduce test script changes [2] [4].Common test tools for embedded smart devices(such as TestQuest)using image parison to determine the status of the target device, although this method to achieve a noninvasive test, but there are two problems, the image capture and transmission consumes a lot of test resources, the different style of phone39。此外，MobileTest 完成測(cè)試任務(wù)的時(shí)間時(shí)15天，比TestQuest 的測(cè)試效率要高。測(cè)試的內(nèi)容是根據(jù)這兩個(gè)系統(tǒng)各自已經(jīng)建立好的回歸測(cè)試用例對(duì)新的智能手機(jī)進(jìn)行回歸測(cè)試，從而比較這兩個(gè)測(cè)試工具的測(cè)試效率和腳本的可維護(hù)性。系統(tǒng)評(píng)估為了評(píng)價(jià)本系統(tǒng)的有效性，我們?cè)O(shè)計(jì)了一個(gè)比較實(shí)驗(yàn)。⑵智能性測(cè)試控制Agent能夠根據(jù)用戶選擇的測(cè)試目標(biāo)，自動(dòng)生成ECA規(guī)則表，并根據(jù)ECA規(guī)則，進(jìn)行推理并采取相應(yīng)的動(dòng)作。⑵ 通過和腳本解釋器交互，實(shí)現(xiàn)異步的事件通知和交互測(cè)試用例的執(zhí)行。⑵ 智能性當(dāng)目標(biāo)設(shè)備Agent獲取到一個(gè)變化的被測(cè)系統(tǒng)狀態(tài)或信息時(shí)，它會(huì)根據(jù)推理規(guī)則，僅僅把和本次目標(biāo)相關(guān)的信息發(fā)送給測(cè)試控制Agent。本系統(tǒng)中它接收從PC機(jī)中接收到的控制命令，然后在智能設(shè)備中進(jìn)行相應(yīng)的操作，包括模擬鍵盤事件，截取屏幕并返回給PC，以及根據(jù)知識(shí)庫中的配置的測(cè)試目標(biāo)，通過推理，有所選擇的將必需的狀態(tài)信息主動(dòng)通知測(cè)試宿主機(jī)。專業(yè)英語期末考查第3頁用戶接口層測(cè)試管理與配置腳本編輯器虛擬手機(jī)測(cè)試控制層測(cè)試結(jié)果驗(yàn)證測(cè)試資源庫測(cè)試腳步執(zhí)行測(cè)試環(huán)境控制測(cè)試過程監(jiān)控Agent通訊層設(shè) 備agent層Synblan Agent藍(lán)牙 GPRS 3G AT視窗的移動(dòng)Agent定制AgentAT 接口圖1 測(cè)試系統(tǒng)的整體架構(gòu) 系統(tǒng)基本執(zhí)行流程測(cè)試過程是對(duì)真實(shí)用戶使用手機(jī)時(shí)“輸入－反饋”模型的一個(gè)模擬。此外，考慮到目標(biāo)設(shè)備處于復(fù)雜的網(wǎng)絡(luò)環(huán)境中，我們利用網(wǎng)絡(luò)環(huán)境Agent來控制目標(biāo)設(shè)備所處的網(wǎng)絡(luò)信號(hào)，從而實(shí)現(xiàn)對(duì)設(shè)備所處網(wǎng)絡(luò)環(huán)境的控制。常見的嵌入式智能設(shè)備測(cè)試工具(比如TestQuest)使用圖像比對(duì)來判斷目標(biāo)設(shè)備的狀態(tài), 這種方法雖然實(shí)現(xiàn)了非侵入性的測(cè)試,但是存在兩個(gè)問題,圖片的抓取和傳送消耗了大量測(cè)試資源,不同手機(jī)的用戶界面風(fēng)格變化很大,實(shí)際的設(shè)備中,當(dāng)重要的事件發(fā)生時(shí),只要操作系統(tǒng)相同,敏感事件的捕獲方式也是一樣,測(cè)試用例不會(huì)因?yàn)榻缑娴淖兓兓?。Yu Qi、David Hung 和 Eric Wong [3] 提出了一個(gè)基于Agent 技術(shù)的Web 應(yīng)用程序測(cè)試方法。將Agent技術(shù)應(yīng)用于測(cè)試領(lǐng)域已經(jīng)有一些相關(guān)的研究，下面是具體的介紹。這些設(shè)備的大都具有嵌入式操作系統(tǒng)的支持, 并運(yùn)行著越來越豐富的應(yīng)用程序。Comment: Cost model has been widely used in the puter field as a way to evaluate whether a program is excellent or quite a number of researchers in puter field has proposed various kinds of cost models for GPU, of which most are under certain this paper give us a new perception of cost model for GPU in generalpurpose parallelization cost model for GPU can be generally applied for many application authors attempt to estimate the cost they take the GPU initialization cost, transmission of data cost as well as the program execution cost into aspect use a special algorithm to calculate the th