cee_calendar_microbes微生物和過敏性疾病-資料下載頁(yè)
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【正文】 aphylaxis (itching,wheezing, labored respiration, convulsions) ?2. Elevated levels of plasma histamine ?3. Induction of peanut specific IgE Peanut IgE ng/ml 0 100 200 300 400 500 0 2500 5000 7500 10000 ? Histamine ng/ml PN/HP PBS PBS/CT PN PN/CT HP/PBS Helminth infection (HP) does not induce an allergic response to a food antigen Bashir et al J. Immunol. 2022, 169:3284 0 250 500 750 1000 PN/CT PN HP/PN/CT HP/PBS PBS/CT Peanut IgE ng/ml 0 1000 2022 3000 4000 ? Histamine ng/ml Helminth infection protects against peanut allergy Bashir et al J. Immunol. 2022, 169:3284 Counterregulation hypothesis TH1 TH2 Organ specific auto immune disease Allergic disease INFLAMMATION IL10 (TGFb) Inhibitory Adapted from WillsKarp, et al , 2022:69 Helminths Viruses Bacteria Protozoa Commensal gut Microflora Commensal gut Microflora Protozoa Viruses Bacteria CD4+ regulatory T cells CD8+ T cells B cells Dendritic cells Monocytes/ macrophages Epithelial cells PNIgE ng/ml D Histamine 0 2500 5000 7500 10000 0 1000 2022 3000 Mice lacking TLR4, the receptor for bacterial LPS, are highly susceptible to an allergic response to peanut plus CT PNIgE ng/ml D Histamine 0 1000 2022 3000 0 1000 2022 3000 Removal of gut bacteria by antibiotic treatment induces an allergic response to peanut in TLR4 positive mice T T B B T T B B B B T Immature (or mature?) DC in GALT (PP, MLN?) Tr1 Tr1 Tr1 Th3 Th3 Th3 IL10 TGFb TGFb IL10 TLR4 IFNg IgE Allergy is induced in the absence of TLR4 signaling by luminal bacteria
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