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【正文】 mly divided to receive a single . dose of 40, 20, 10 and 0 mg/kg dose of KNT009 and 20 mg/kg of gatifloxacin respectively, and the blood pressure, ECG, respiratory rate and width of dogs were measured. Results: No obvious effects on spontaneous activities and pulldown abilities in mice were observed. The systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate and respiratory rate of dogs were decreased, the QT interval was prolonged and the respiratory width was increased in dogs. There were doserespose relationship, however, these parameters return to normal within 3 h. Conclusion: KNT009 has some effects on cardiovascular and respiratory systems in dogs, leading to blood pressure, heart rate and respiratory rate decrease and QT internal and respiratory width increase.Key words: KNT009。 safety pharmacology。 cardiovascular system。 respiratory syste。 nervous system（Times New Roman，小四號，兩端對齊，）說明：關鍵詞另起行，“關鍵詞”三字空二格用黑體三號字打印，并加冒號。冒號后空二格用楷體四號字打出關鍵詞3～5個。 8
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