抗寄生蟲藥antiparasitedrugs——方三華-資料下載頁
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【正文】 nd other forms of heterophyiasis. fascioliasis, Praziquantel 吡喹酮 Mechanism of actions ? Increase the permeability of cell membranes to calcium, resulting in paralysis, dislodgement, and death. ? In schistosome infections, praziquantel is effective against adult worms and immature stages ? Prophylactic effect against cercarial （尾蚴）infection. Praziquantel 吡喹酮 Adverse effects ? Most frequent are headache, dizziness, drowsiness, and lassitude。 ? Others include nausea, vomiting, abdominal pain, pruritus, urticaria, arthralgia, myalgia, and lowgrade fever. ? Mild and transient elevations of liver enzymes Praziquantel 吡喹酮 Filariasis ? 淋巴管炎、淋巴結炎 ? 橡皮腫、乳糜尿 Diethylcarbamazine 乙胺嗪 Anthelmintic Actions Diethylcarbamazine immobilizes microfilariae （ 微絲蚴） and alters their surface structure, displacing them from tissues and making them more susceptible to destruction by host defense mechanisms. Clinical Uses Wuchereria Bancrofti, Brugia Malayi, Brugia Timori, and Loa Loa Adverse effects Generally mild and transient Include headache, malaise, anorexia, weakness, nausea, vomiting, and dizziness. Anthelmintic Drugs 驅 (蠕 )蟲藥 Anthelmintic Drugs –Albendazole （阿 苯達唑 ） Pharmacological effects ?A broadspectrum oral anthelmintic, is the drug of choice for treatment of hydatid disease （包蟲?。゛nd cysticercosis. （囊蟲病） ?Also used for the treatment of pinworm （蟯蟲）and hookworm infections, ascariasis（蛔蟲?。? , trichuriasis（鞭蟲病） and strongyloidiasis（類圓線蟲?。? Anthelmintic Drugs Albendazole Adverse effects ?Mild and transient epigastric distress, diarrhea, headache, nausea, dizziness, lassitude, and insomnia can occur. ?Abdominal distress, headaches, fever, fatigue, alopecia, increases in liver enzymes, and pancytopenia in longterm use Anthelmintic Drugs Albendazole ?A synthetic benzimidazole that has a wide spectrum of anthelmintic activity Anthelmintic Drugs Mebendazole 1. Piperazine （ 哌嗪） :蛔蟲、絳蟲 2. Levamisole （ 左旋咪唑）：蛔蟲、鉤蟲、絳蟲 3. Pyrantel （ 噻嘧啶）：蛔蟲、鉤蟲、絳蟲 4. Niclosamide （ 氯硝柳胺）：絳蟲 5. Praziquantel （ 吡喹酮）：吸蟲、絳蟲 Anthelmintic Drugs Other Anthelmintic Drugs
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