屠呦呦事跡介紹共5則(編輯修改稿)
2024-10-25 09:21 本頁面
【文章內(nèi)容簡介】 of water, strain the liquid, and drink.” She realized that the standard procedure of boiling and hightemperature extraction could destroy the active this idea in mind, Tu redesigned the extraction process, performing it at low temperatures with ether as the also removed a harmful acidic portion of the extract that did not contribute to antimalarial activity, tracked the material to the leaves rather than other parts of the plant, and figured out when to harvest the herb to maximize innovations boosted potency and slashed a March 1972 meeting of the Project 523 group39。s key participants, she reported that the neutral plant extract —number 191—obliterated Plasmodia in the blood of mice and branch to bedsideLater that year, Tu and her team tested the substance on 21 people with malaria in the Hainan Province, an island off the southern coast of half the patients were infected with Plasmodium falciparum, the deadliest of the microbial miscreants, and about half were infected with Plasmodium vivax, the most mon cause of a disease variant that is characterized by recurring both groups, fever disappeared rapidly, as did bloodborne the meantime, Tu started to home in on the active ingredient, using chromatography to separate the extract39。s November 8, 1972, she and her colleagues obtained the pure named it Qinghaosu(literally, the principle of Qinghao)and it is now monly called artemisinin in the and her colleagues subsequently determined that it had an unusual proved to be a sesquiterpene lactone with a peroxide group, a pletely different kind of pound than any known antimalarial studies would show that the peroxide portion is essential for its lethal effects on the clinical trials on 529 malaria cases confirmed that the crystal they had isolated delivers the antimalarial scientists from other institutes then joined efforts to improve the extraction procedures and conduct clinical first English language report about artemisinin was in December 1979。as was customary at the time in China, the authors were that point, the Chinawide Qinghaosu research group had given the substance to more than 2000 patients, some of whom had chloroquineresistant malaria addition, the drug cured 131 of 141 individuals with cerebral malaria, a particularly severe form of the studies on a small number of cases suggested that the drug acted more quickly than chloroquine investigators reported no harmful side paper drew international October 1981, the scientific working group on the chemotherapy of malaria, sponsored by the WHO, the World Bank, and United Nations Development Business, invited Tu to present her findings at its fourth talk evoked an enthusiastic told the audience not only about artemisinin, but also about some of its chemical 1973, as part of her structural studies, Tu had modified artemisinin to generate a pound called later found that it delivers ten times more punch than artemisinin and that it reduces risk of disease pound provided the basis for other artemisininderived in the mid 1970s, Guoqiao Li(Guangzhou College of Traditional Chinese Medicine)performed clinical trials with artemisinin and these all delivered more therapeutic clout than did standard drugs such as chloroquine and derivatives tend to hold up better than the parent pound in the body, and they form the foundation of today3
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