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? 在尋找低血糖的路上不要過于迷信化驗(yàn),在實(shí)踐中化驗(yàn) 10次也許比不上問話 1次。 Leuven l 研究 ? 與常規(guī)治療相比,胰島素強(qiáng)化治療使 ICU期間的死亡率顯著降低 (4. 6%對(duì) 8. 0%, P0. 05) ? 強(qiáng)化治療還可使總體住院死亡率以及敗血癥、急性腎衰竭等合并癥顯著減少。 ? ( 3)中、小手術(shù)術(shù)后一般的血糖控制目標(biāo)為空腹血糖 ,隨機(jī)血糖 。 ? —— 《 2022中國糖尿病指南討論版》 2022 ADA指南 ? Older adults who are functional, cognitively intact, and have significant life expectancy should receive diabetes care using goals developed for younger adults. (E) ? Glycemic goals for older adults not meeting the above criteria may be relaxed using individual criteria, but hyperglycemia leading to symptoms or risk of acute hyperglycemic plications should be avoided in all patients. (E) ? 75歲以上老年或合并有心、腦、腎和肝臟等重要臟器病變者,空腹血糖 ≤ mmol/L或餐后血糖 ≤ mmol/L。 ? Agree individualised blood glucose targets for selfmonitoring. ? Advise women who need intensification of hypoglycaemic therapy to increase the frequency of selfmonitoring to include fasting and a mixture of pre and postprandial levels. ? Offer monthly HbA1c ? Advise women to aim for an HbA1c below %, if safe. ? Inform women that any reduction in HbA1c may reduce risks. ? Advise women with HbA1c above 10% to avoid pregnancy. ? Do not offer rapid optimisation of glycaemic control until after retinal assessment and treatment are pleted. ? ——National Institute for Health and Clinical Excellence( NICE)英國國家衛(wèi)生醫(yī)療質(zhì)量標(biāo)準(zhǔn)署 妊娠期間血糖控制標(biāo)準(zhǔn) ? 空腹,餐前,或睡前血糖 ,餐后 1小時(shí) ≤ mmol/L;或餐后 2小時(shí)血糖≤; HbA1c盡可能控制在 %以下。 ? 推薦意見:血糖超過 ;( 2)血糖低于 注射治療。 二、對(duì)于 ICU患者進(jìn)行強(qiáng)化血糖控制的質(zhì)疑 ? 近年來,多項(xiàng)同類研究對(duì)于 Leuven研究發(fā)現(xiàn)提出質(zhì)疑。當(dāng)然能做出這樣的決斷并非容易,它不僅需要勇氣,而且需要堅(jiān)實(shí)的理論基礎(chǔ)和豐富的實(shí)踐經(jīng)驗(yàn)作后盾。 ? 強(qiáng)化血糖控制組嚴(yán)重低血糖 (血糖 ≤40 ms/d1)的發(fā)生率顯著